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Literature summary for 1.1.1.64 extracted from

  • le Lain, R.; Barrell, K.J.; Saeed, G.S.; Nicholls, P.J.; Simons, C.; Kirby, A.; Smith, H.J.
    Some coumarins and triphenylethene derivatives as inhibitors of human testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD type 3): further studies with tamoxifen on the rat testes microsomal enzyme (2002), J. Enzyme Inhib. Med. Chem., 17, 93-100.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(RS)-3(2,3,3-triphenyl-prop-2-enoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione IC50: 0.00915 mM Homo sapiens
(RS)-3(3'-phenylpropoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione IC50: 0.0421 mM Homo sapiens
4-Methylumbelliferone IC50: 0.0019 mM Homo sapiens
clomiphene IC50: 0.0762 mM Homo sapiens
tamoxifen IC50: 0.098 mM, time-dependent and irreversible Homo sapiens
umbelliferone IC50: 0.0014 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androstenedione + NADPH + H+
-
 Homo sapiens testosterone + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-HSD type 3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
 IC50: 0.0014 mM Homo sapiens umbelliferone
0.0019
-
 IC50: 0.0019 mM Homo sapiens 4-Methylumbelliferone
0.00915
-
 IC50: 0.00915 mM Homo sapiens (RS)-3(2,3,3-triphenyl-prop-2-enoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione
0.0421
-
 IC50: 0.0421 mM Homo sapiens (RS)-3(3'-phenylpropoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione
0.0762
-
 IC50: 0.0762 mM Homo sapiens clomiphene
0.098
-
 IC50: 0.098 mM, time-dependent and irreversible Homo sapiens tamoxifen