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Literature summary for 1.1.1.62 extracted from

  • Hilborn, E.; Stal, O.; Jansson, A.
    Estrogen and androgen-converting enzymes 17beta-hydroxysteroid dehydrogenase and their involvement in cancer with a special focus on 17beta-hydroxysteroid dehydrogenase type 1, 2, and breast cancer (2017), Oncotarget, 8, 30552-30562 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics a high HSD17B1 to HSD17B2 ratio, as well as high HSD17B1 on its own is associated with worse prognosis and increased risk of recurrence in patients with ERalpha-positive tumors. An increased copy number of the HSD17B1 gene is correlated with decreased breast cancer survival Homo sapiens
diagnostics the expression of 17beta-hydroxysteroid dehydrogenases 1 and 2 alone and in combination predicts outcome of patients with breast cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the status of inhibitors against 17beta-hydroxysteroid dehydrogenases 1 is reviewed Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34950
-
calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NADP+ Homo sapiens
-
estrone + NADPH + H+
-
?
estrone + NADPH + H+ Homo sapiens most active enzyme in regards to 17beta-estradiol production 17beta-estradiol + NADP+
-
?
testosterone + NAD+ Homo sapiens
-
androst-4-ene-3,17-dione + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
-
-
Homo sapiens P37059
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast epithelial cell
-
Homo sapiens
-
breast epithelium low level Homo sapiens
-
colon HSD17B2 is normally expressed in the epithelial cells of the colon lumen, and to a lesser extent in the crypt epithelium small intestine endometrium Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
lobular carcinoma cell HSD17B2 expression is significantly higher in invasive lobular carcinoma (ILC) than in invasive ductal carcinoma Homo sapiens
-
lung
-
Homo sapiens
-
mammary ductal carcinoma cell HSD17B2 expression is significantly higher in invasive lobular carcinoma (ILC) than in invasive ductal carcinoma Homo sapiens
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NAD(P)+
-
Homo sapiens estrone + NAD(P)H + H+
-
?
17beta-estradiol + NADP+
-
Homo sapiens estrone + NADPH + H+
-
?
androstendiol + NAD(P)+
-
Homo sapiens dehydroepiandrosterone + NAD(P)H + H+
-
?
dehydroepiandrosterone + NAD(P)H + H+
-
Homo sapiens androstendiol + NAD(P)+
-
?
dehydroepiandrosterone + NADPH + H+
-
Homo sapiens androstenediol + NADP+
-
?
estrone + NAD(P)H + H+
-
Homo sapiens 17beta-estradiol + NAD(P)+
-
?
estrone + NADPH + H+
-
Homo sapiens 17beta-estradiol + NADP+
-
?
estrone + NADPH + H+ most active enzyme in regards to 17beta-estradiol production Homo sapiens 17beta-estradiol + NADP+
-
?
testosterone + NAD(P)+
-
Homo sapiens androstenedione + NAD(P)H + H+
-
?
testosterone + NAD+
-
Homo sapiens androst-4-ene-3,17-dione + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
Homo sapiens
17beta-HSD2
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase 1
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens
HSD17B1
-
Homo sapiens
HSD17B2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HSD17B2 expression is reduced in breast cancer compared with benign tumors down
Homo sapiens expression of HSD17B2 is increased in ERalpha-negative breast cancer up
Homo sapiens HSD17B1 expression is increased in breast cancer compared with unchanged tissue up
Homo sapiens HSD17B2 expression is significantly higher in invasive lobular carcinoma (ILC) than in invasive ductal carcinoma up
Homo sapiens in non-small cell lung cancer (NSCLC) the expression of HSD17B1 is increased as compared with healthy tissue up

General Information

General Information Comment Organism
drug target inhibition of 17beta-hydroxysteroid dehydrogenases 1 is proposed to be a prime candidate for inhibition in patients who develop aromatase inhibitor resistance or in combination with aromatase inhibitors as a first line treatment Homo sapiens
drug target inhibition of 17beta-hydroxysteroid dehydrogenases 1 may be a prime candidate for inhibition in patients with breast cancer who develop aromatase inhibitor resistance or in combination with aromatase inhibitors as a first line treatment Homo sapiens
drug target the ratio of HSD17B1 to HSD17B2 is a good indicator of tamoxifen treatment benefit, as post-menopausal patients with tumors expressing a high HSD17B1/HSD17B2 protein ratio have less benefit from tamoxifen treatment Homo sapiens
physiological function the expression of 17beta-hydroxysteroid dehydrogenase 1 and 2 alone and in combination predicts outcome of patients with breast cancer Homo sapiens