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Literature summary for 1.1.1.62 extracted from

  • Ferrante, T.; Adinolfi, S.; DArrigo, G.; Poirier, D.; Daga, M.; Lolli, M.L.; Balliano, G.; Spyrakis, F.; Oliaro-Bosso, S.
    Multiple catalytic activities of human 17beta-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors (2020), Biochimie, 170, 106-117 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli BL21 (DE3) Homo sapiens
overexpression in Escherichia coli BL21 (DE3) Codon Plus RP cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
-
Homo sapiens
(4aR,6aS,7S)-7-[heptyl(methyl)amino]-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
-
Homo sapiens
17beta-[(N-decyl)formamido]-4-aza-5alpha-androstan-3-one
-
Homo sapiens
17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
-
Homo sapiens
17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one
-
Homo sapiens
17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
-
Homo sapiens
17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
-
Homo sapiens
N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
-
Homo sapiens
N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
-
Homo sapiens
N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NADPH + H+ Homo sapiens steroid hormone pathway 17beta-estradiol + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56937
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrotestosterone + NADPH + H+
-
Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
?
estrone + NADPH + H+
-
Homo sapiens estradiol + NADP+
-
?
estrone + NADPH + H+
-
Homo sapiens 17beta-estradiol + NAD(P)+
-
?
estrone + NADPH + H+ steroid hormone pathway Homo sapiens 17beta-estradiol + NAD(P)+
-
?
progesterone + NADPH + H+
-
Homo sapiens 4-preggnen-3beta-ol-20-one + NADP+
-
?

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 7
-
Homo sapiens
HSD17B7
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00041
-
pH and temperature not specified in the publication Homo sapiens (4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
0.00041
-
pH 7.4, 37°C, reduction of estrone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
0.0006
-
pH and temperature not specified in the publication, substrate: progesterone Homo sapiens (4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
0.0006
-
pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
0.0007
-
pH and temperature not specified in the publication Homo sapiens N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.0007
-
pH 7.4, 37°C, reduction of estrone Homo sapiens 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
0.00096
-
pH and temperature not specified in the publication Homo sapiens (4aR,6aS,7S)-7-[heptyl(methyl)amino]-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
0.00112
-
pH and temperature not specified in the publication Homo sapiens N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.00119
-
pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
0.00291
-
pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.00291
-
pH 7.4, 37°C, reduction of estrone Homo sapiens 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
0.00316
-
pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
0.00332
-
pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.00332
-
pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
0.00396
-
pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.00396
-
pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
0.00424
-
pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
0.00578
-
pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.00578
-
pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one
0.00601
-
pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one

General Information

General Information Comment Organism
physiological function the enzyme is involved in the metabolism of steroid hormones and in the biosynthesis of cholesterol Homo sapiens