Cloned (Comment) | Organism |
---|---|
overexpression in Escherichia coli BL21 (DE3) | Homo sapiens |
overexpression in Escherichia coli BL21 (DE3) Codon Plus RP cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one | - |
Homo sapiens | |
(4aR,6aS,7S)-7-[heptyl(methyl)amino]-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one | - |
Homo sapiens | |
17beta-[(N-decyl)formamido]-4-aza-5alpha-androstan-3-one | - |
Homo sapiens | |
17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | - |
Homo sapiens | |
17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one | - |
Homo sapiens | |
17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one | - |
Homo sapiens | |
17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | - |
Homo sapiens | |
N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | - |
Homo sapiens | |
N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | - |
Homo sapiens | |
N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADPH + H+ | Homo sapiens | steroid hormone pathway | 17beta-estradiol + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P56937 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrotestosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-androstane-3beta,17beta-diol + NADP+ | - |
? | |
estrone + NADPH + H+ | - |
Homo sapiens | estradiol + NADP+ | - |
? | |
estrone + NADPH + H+ | - |
Homo sapiens | 17beta-estradiol + NAD(P)+ | - |
? | |
estrone + NADPH + H+ | steroid hormone pathway | Homo sapiens | 17beta-estradiol + NAD(P)+ | - |
? | |
progesterone + NADPH + H+ | - |
Homo sapiens | 4-preggnen-3beta-ol-20-one + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-hydroxysteroid dehydrogenase type 7 | - |
Homo sapiens |
HSD17B7 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00041 | - |
pH and temperature not specified in the publication | Homo sapiens | (4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one | |
0.00041 | - |
pH 7.4, 37°C, reduction of estrone | Homo sapiens | 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.0006 | - |
pH and temperature not specified in the publication, substrate: progesterone | Homo sapiens | (4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one | |
0.0006 | - |
pH 7.4, 37°C, reduction of progesterone | Homo sapiens | 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.0007 | - |
pH and temperature not specified in the publication | Homo sapiens | N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | |
0.0007 | - |
pH 7.4, 37°C, reduction of estrone | Homo sapiens | 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.00096 | - |
pH and temperature not specified in the publication | Homo sapiens | (4aR,6aS,7S)-7-[heptyl(methyl)amino]-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one | |
0.00112 | - |
pH and temperature not specified in the publication | Homo sapiens | N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | |
0.00119 | - |
pH 7.4, 37°C, reduction of dihydrotestosterone | Homo sapiens | 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.00291 | - |
pH and temperature not specified in the publication, substrate: progesterone | Homo sapiens | N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | |
0.00291 | - |
pH 7.4, 37°C, reduction of estrone | Homo sapiens | 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.00316 | - |
pH 7.4, 37°C, reduction of progesterone | Homo sapiens | 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.00332 | - |
pH and temperature not specified in the publication, substrate: progesterone | Homo sapiens | N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | |
0.00332 | - |
pH 7.4, 37°C, reduction of dihydrotestosterone | Homo sapiens | 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.00396 | - |
pH and temperature not specified in the publication, substrate: progesterone | Homo sapiens | N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | |
0.00396 | - |
pH 7.4, 37°C, reduction of dihydrotestosterone | Homo sapiens | 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.00424 | - |
pH 7.4, 37°C, reduction of progesterone | Homo sapiens | 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | |
0.00578 | - |
pH and temperature not specified in the publication, substrate: progesterone | Homo sapiens | N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide | |
0.00578 | - |
pH 7.4, 37°C, reduction of dihydrotestosterone | Homo sapiens | 17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one | |
0.00601 | - |
pH 7.4, 37°C, reduction of progesterone | Homo sapiens | 17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the metabolism of steroid hormones and in the biosynthesis of cholesterol | Homo sapiens |