Literature summary for 1.1.1.62 extracted from

Herman, B.E.; Szabo, J.; Bacsa, I.; Woelfling, J.; Schneider, G.; Balint, M.; Hetenyi, C.; Mernyak, E.; Szecsi, M.
Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17beta-hydroxysteroid dehydrogenase type 1 (2016), J. Enzyme Inhib. Med. Chem., 36 (Suppl.3), 61-69.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(13alpha)-3-hydroxyestra-1(10),2,4-trien-17-one	inhibits the enzyme activity effectively, enzyme affinity is similar to that of the natural estrone substrate	Homo sapiens
3-hydroxy-13alpha-D-secooxime	displays an outstanding cofactor dependence, i.e. more efficient inhibition in the presence of NADH than NADPH	Homo sapiens
3-hydroxy-13beta-D-secoalcohol	displays an outstanding cofactor dependence, i.e. more efficient inhibition in the presence of NADH than NADPH	Homo sapiens
D-secoalcohol estrone	-	Homo sapiens
D-secooxime	-	Homo sapiens
additional information	inhibitory effects of 13-epimeric estrones, D-secooxime and D-secoalcohol estrone compounds on placental enzyme 17beta-HSD1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14061	-	-

Synonyms

Synonyms	Comment	Organism
17beta-HSD1	-	Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00007	-	pH and temperature not specified in the publication	Homo sapiens	3-hydroxy-13alpha-D-secooxime
0.0012	-	pH and temperature not specified in the publication	Homo sapiens	(13alpha)-3-hydroxyestra-1(10),2,4-trien-17-one

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Release 2023.1 (January 2023)