Application | Comment | Organism |
---|---|---|
medicine | isoform 17betaHSD6 is expressed in estrogen receptor beta-positive epithelial cells of the human prostate. In prostate cancers of Gleason grade higher than 3, both estrogen receptor beta and isoform 17betaHSD6 are undetectable | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14756 | isoform 17betaHSD6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | in prostate cancers of Gleason grade higher than 3, both estrogen receptor beta and isoform 17betaHSD6 are undetectable | Homo sapiens | - |
prostate | expressed in estrogen receptor beta-positive epithelial cells of the human prostate | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3,17-dione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-hydroxysteroid dehydrogenase type 6 | - |
Homo sapiens |
17betaHSD6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | 17beta-hydroxysteroid dehydrogenase type 6 converts the androgen 5alpha-dihydrotestosterone to the estrogen 5alpha-androstane-3beta,17beta-diol, and this leads to activation of the estrogen receptor beta reporter. This conversion of dihydrotestosterone occurs at concentrations that are in the physiological range of this hormone in the prostate | Homo sapiens |