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Literature summary for 1.1.1.62 extracted from

  • Starcevic, S.; Brozic, P.; Turk, S.; Cesar, J.; Lanisnik Rizner, T.; Gobec, S.
    Synthesis and biological evaluation of (6- and 7-Phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (2011), J. Med. Chem., 54, 248-261.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
erxpression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-acetyl-2-oxo-2H-chromen-7-yl trifluoromethanesulfonate IC50 value of 360 nM against recombinant enzyme in bacterial homogenate Homo sapiens
3-acetyl-7-(4-hydroxyphenyl)-2H-chromen-2-one IC50 value of 270 nM against recombinant enzyme in bacterial homogenate, and high selectivity for isoform 17beta-HSD1 over 17beta-HSD2 and against the alpha and beta estrogen receptors Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
-
-

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens