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Literature summary for 1.1.1.62 extracted from

  • Kruchten, P.; Werth, R.; Bey, E.; Oster, A.; Marchais-Oberwinkler, S.; Frotscher, M.; Hartmann, R.W.
    Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells (2009), J. Steroid Biochem. Mol. Biol., 114, 200-206.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,1':4',1''-terphenyl-3,3''-diol
-
Homo sapiens
3,3'-pyridine-2,5-diyldiphenol
-
Homo sapiens
3-[4-(4-hydroxyphenyl)thiophen-2-yl]phenol
-
Homo sapiens
3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol
-
Homo sapiens
3-[5-(4-hydroxyphenyl)thiophen-3-yl]phenol
-
Homo sapiens
4-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylphenol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-47D cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NADPH + H+
-
Homo sapiens estradiol-17beta + NADP
-
?

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens
17betaHSD1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000046
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA Homo sapiens 4-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylphenol
0.000069
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA Homo sapiens 3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol
0.000077
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA Homo sapiens 3-[4-(4-hydroxyphenyl)thiophen-2-yl]phenol
0.000101
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA Homo sapiens 3,3'-pyridine-2,5-diyldiphenol
0.000151
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA Homo sapiens 3-[5-(4-hydroxyphenyl)thiophen-3-yl]phenol
0.000173
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA Homo sapiens 1,1':4',1''-terphenyl-3,3''-diol