Application | Comment | Organism |
---|---|---|
medicine | 17beta-HSD1 is overexpressed in many breast tumors. Thus, it is an attractive target for the treatment of these diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(3-hydroxyphenyl)quinolin-6-ol | 0.001 mM, 63% inhibition, substrate: estrone | Homo sapiens | |
3-(2-naphthyl)phenol | 0.001 mM, 61% inhibition, substrate: estrone | Homo sapiens | |
3-(3-hydroxyphenyl)quinolin-7-ol | 0.001 mM, 57% inhibition, substrate: estrone | Homo sapiens | |
3-(6-hydroxy-2-naphthyl)benzoic acid | 0.001 mM, 76% inhibition, substrate: estrone | Homo sapiens | |
3-(quinolin-3-yl)phenol | 0.001 mM, 18% inhibition, substrate: estrone | Homo sapiens | |
5-(6-hydroxy-2-naphthyl)pyridin-3-ol | 0.001 mM, 58% inhibition, substrate: estrone | Homo sapiens | |
6-(3-hydroxyphenyl)-1-naphthol | 0.001 mM, 23% inhibition, substrate: estrone | Homo sapiens | |
6-(3-hydroxyphenyl)-2-naphthol | 0.0001 mM, 91% inhibition, substrate: estrone | Homo sapiens | |
6-(3-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one | 0.001 mM, 23% inhibition, substrate: estrone | Homo sapiens | |
6-(4-hydroxyphenyl)-1-naphthol | 0.001 mM, 55% inhibition, substrate: estrone | Homo sapiens | |
6-pyridin-3-yl-2-naphthol | 0.001 mM, 32% inhibition, substrate: estrone | Homo sapiens | |
6-[4-(hydroxymethyl)phenyl]-2-naphthol | 0.001 mM, 13% inhibition, substrate: estrone | Homo sapiens | |
7-(3-hydroxyphenyl)-2-naphthol | 0.001 mM, 62% inhibition, substrate: estrone | Homo sapiens | |
N-[3-(6-hydroxy-2-naphthyl)phenyl]acetamide | 0.001 mM, 19% inhibition, substrate: estrone | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | 17beta-HSD1 is overexpressed in many breast tumors | Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADPH + H+ | - |
Homo sapiens | estradiol-17beta + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |