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Literature summary for 1.1.1.62 extracted from

  • Kristan, K.; Krajnc, K.; Konc, J.; Gobec, S.; Stojan, J.; Lanisnik Rizner, T.
    Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase (2005), Steroids, 70, 626-635.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,5,7,4'-tetrahydroxyflavone IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata
3,7-dihydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata
3-hydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one; IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata
5,7-dihydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata
5-hydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata
5-methoxyflavone IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata
coumestrol IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata

Organism

Organism UniProt Comment Textmining
Curvularia lunata
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydroxyestra-4-en-3-one + NADP+
-
Curvularia lunata estra-4-en-3,17-dione + NADPH + H+
-
r

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 5,7-dihydroxyflavone
0.001
-
IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 3-hydroxyflavone
0.001
-
IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 5-hydroxyflavone
0.001
-
IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 3,7-dihydroxyflavone
0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata 3-hydroxyflavone
0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata coumestrol
0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata 5-methoxyflavone
0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata 3,5,7,4'-tetrahydroxyflavone