Literature summary for 1.1.1.62 extracted from

Reed, M.J.; Rea, D.; Duncan, L.J.; Parker, M.G.
Regulation of estradiol 17beta-hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells (1994), Endocrinology, 135, 4-9.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
estrone + NADH	Homo sapiens	trans-retinoic acid increases expression of the enzyme in a dose-dependent and time-dependent manner in T47D breast cancer cells, the increased expression is associated with an increase in reductive activity of the enzyme	estradiol-17beta + NAD+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-431 cell	-	Homo sapiens	-
ovarian cancer cell	-	Homo sapiens	-
T47D cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
estrone + NADH	trans-retinoic acid increases expression of the enzyme in a dose-dependent and time-dependent manner in T47D breast cancer cells, the increased expression is associated with an increase in reductive activity of the enzyme	Homo sapiens	estradiol-17beta + NAD+	-	?

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Release 2023.1 (January 2023)