Application | Comment | Organism |
---|---|---|
medicine | binding of equilin at the active site of the enzyme is the basis for inhibition of reduction of estrone to estradiol. One possible outcome of estrogen replacement therapy in vivo can be the reduction of estradiol levels in breast tissues and hence the reduced risk of estrogen-dependent breast cancer | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
ternary complex of the 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one and NADP+ | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
equilin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADH | Homo sapiens | key enzyme responsible for elevated levels of 17beta-estradiol in breast tumor tissues | estradiol-17beta + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | type 1 enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADH | key enzyme responsible for elevated levels of 17beta-estradiol in breast tumor tissues | Homo sapiens | estradiol-17beta + NAD+ | - |
? |