Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | type 1 enzyme | Homo sapiens | 5829 | - |
microsome | type 2 enzyme | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADH | Homo sapiens | exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol | estradiol-17beta + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | - |
Homo sapiens | - |
A-431 cell | epidermoid tumor of the vulva, A431 | Homo sapiens | - |
breast cell line | - |
Homo sapiens | - |
CAOV-3 cell | enzyme type 2 from ovarian tumor: CAOV-3 | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
ovarian cancer cell | enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3 and epidermoid tumor of the vulva, A431 | Homo sapiens | - |
ovary | enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3 | Homo sapiens | - |
OVCAR-3 cell | enzyme type 2 from ovarian tumor: OVCAR-3 | Homo sapiens | - |
T47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD+ | type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone | Homo sapiens | estrone + NADH | - |
? | |
estrone + NADH | exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol | Homo sapiens | estradiol-17beta + NAD+ | - |
? | |
estrone + NADPH + H+ | type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone | Homo sapiens | estradiol-17beta + NADP+ | - |
? | |
additional information | type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 enzyme is a membrane bound isoform reactive with both estradiol and testosterone | Homo sapiens | ? | - |
? | |
testosterone + NADP+ | - |
Homo sapiens | 4-androstene-3,17-dione + NADPH + H+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | cofactor | Homo sapiens |