Literature summary for 1.1.1.53 extracted from

Wu, Y.; Li, L.; Zhou, S.; Shen, Q.; Lin, H.; Zhu, Q.; Sun, J.; Ge, R.S.
Apigenin inhibits rat neurosteroidogenic 5alpha-reductase 1 and 3alpha-hydroxysteroid dehydrogenase (2017), Neurochem. Int., 110, 84-90 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Cos-1 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
apigenin	significant inhibition at 0.1 mM	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00317	-	5alpha-dihydrotestosterone	37°C, pH 7.2	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P50170	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5alpha-dihydrotestosterone + NADPH	-	Rattus norvegicus	5alpha-androstan-3alpha,17beta-diol + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
retinol dehydrogenase 2	-	Rattus norvegicus
RoDH2	-	Rattus norvegicus

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Release 2023.1 (January 2023)