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Literature summary for 1.1.1.53 extracted from
- Mechanism of inhibition of 3alpha, 20beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor (1994), Curr. Biol., 2, 973-980.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystallized with bound inhibitor carbenoxolone, asymmetric tetramer, Tyr152, Lys156 and Ser139 are conserved as the catalytic triade | Streptomyces exfoliatus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carbenoxolone | - |
Streptomyces exfoliatus |  |
| glycyrrhizic acid | - |
Streptomyces exfoliatus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H | Streptomyces exfoliatus | enzyme belongs to the group of short-chain dehydrogenases | ? | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces exfoliatus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H | enzyme belongs to the group of short-chain dehydrogenases | Streptomyces exfoliatus | ? | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | tetrameric, monomers with beta-alpha-beta-motif | Streptomyces exfoliatus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Streptomyces exfoliatus | |
| NADH | - |
Streptomyces exfoliatus | |
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Release 2023.1 (January 2023)
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