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Literature summary for 1.1.1.53 extracted from

  • Ohno, S.; Nakajin, S.; Shinoda, M.
    Ontogeny of testicular steroid dehydrogenase enzymes in pig (3alpha/beta-, 20alpha- and 20beta-): evidence for two forms of 3alpha/beta-hydroxysteroid dehydrogenase (1992), J. Steroid Biochem. Mol. Biol., 42, 17-21.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH + H+ Sus scrofa
-
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
primary bifunctional enzyme, 3alpha/beta-hydroxysteroid and 20beta-hydroxysteroid dehydrogenase, is replaced during maturation by a secondary 3alpha/beta-hydroxysteroid dehydrogenase without 20beta-hydroxysteroid dehydrogenase activity
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH + H+
-
Sus scrofa 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
?
17alpha-hydroxyprogesterone + NADPH + H+
-
Sus scrofa 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
?
5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+ i.e. 5alpha-dihydrotestosterone Sus scrofa 5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Sus scrofa
NADPH
-
Sus scrofa