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Literature summary for 1.1.1.51 extracted from

  • Emanuelsson, I.; Almokhtar, M.; Wikvall, K.; Groenbladh, A.; Nylander, E.; Svensson, A.L.; Fex Svenningsen, A.; Norlin, M.
    Expression and regulation of CYP17A1 and 3?-hydroxysteroid dehydrogenase in cells of the nervous system Potential effects of vitamin D on brain steroidogenesis (2018), Neurochem. Int., 113, 46-55 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxypregnenolone + NAD(P)H + H+ Rattus norvegicus
-
 17alpha-hydroxyprogesterone + NAD(P)+
-
 ?
dehydroepiandrosterone + NAD(P)H + H+ Rattus norvegicus
-
 androstenedione + NAD(P)+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte major site for expression Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxypregnenolone + NAD(P)H + H+
-
 Rattus norvegicus 17alpha-hydroxyprogesterone + NAD(P)+
-
 ?
dehydroepiandrosterone + NAD(P)H + H+
-
 Rattus norvegicus androstenedione + NAD(P)+
-
 ?

Synonyms

Synonyms Comment Organism
3beta-HSD
-
 Rattus norvegicus
3beta-hydroxysteroid dehydrogenase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus 3beta-HSD is suppressed by vitamin D, about 20% at the enzyme activity level and 60% at the mRNA level down

General Information

General Information Comment Organism
metabolism the enzyme is important in all basic steroidogenic pathways Rattus norvegicus