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Literature summary for 1.1.1.50 extracted from

  • Jin, Y.; Stayrook, S.E.; Albert, J.H.; Palackal, N.T.; Penning, T.M.; Lewis, M.
    Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate (2001), Biochemistry, 40, 10161-10168.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
alpha/beta-barrel, NADP+ is bound in an extended conformation, type III isoform Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fluoxetine allosteric interaction Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-pregnan-3,20-dione + NAD(P)H
-
Homo sapiens 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
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