KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000082 | - |
5alpha-pregnan-3,20-dione | reduction | Rattus norvegicus | |
0.00071 | - |
NADPH | - |
Rattus norvegicus | |
0.0014 | - |
3alpha-hydroxy-5alpha-pregnan-20-one | oxidation | Rattus norvegicus | |
0.0016 | - |
NADP+ | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
non-dissociating electrophoresis | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
micro-purification procedure | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypophysis | female | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.04 | - |
5alpha-pregnan-3,20-dione | Rattus norvegicus |
0.323 | - |
3alpha-hydroxy-5alpha-pregnan-20-one | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
Rattus norvegicus | 17beta-hydroxy-5alpha-androstan-3-one + NADPH | - |
? | |
5alpha-pregnan-3,20-dione + NAD(P)H | - |
Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 36000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
NADPH:5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | preference for | Rattus norvegicus |