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Literature summary for 1.1.1.50 extracted from

  • Campbell, J.S.; Karavolas, H.J.
    Purification of the NADPH:5alpha-dihydroxyprogesterone 3alpha-hydroxysteroid oxidoreductase from female rat pituitary cytosol (1990), J. Steroid Biochem. Mol. Biol., 37, 215-222.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000082
-
5alpha-pregnan-3,20-dione reduction Rattus norvegicus
0.00071
-
NADPH
-
Rattus norvegicus
0.0014
-
3alpha-hydroxy-5alpha-pregnan-20-one oxidation Rattus norvegicus
0.0016
-
NADP+
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
non-dissociating electrophoresis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
micro-purification procedure Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hypophysis female Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.04
-
5alpha-pregnan-3,20-dione Rattus norvegicus
0.323
-
3alpha-hydroxy-5alpha-pregnan-20-one Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
Rattus norvegicus 17beta-hydroxy-5alpha-androstan-3-one + NADPH
-
?
5alpha-pregnan-3,20-dione + NAD(P)H
-
Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 36000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
NADPH:5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH preference for Rattus norvegicus