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Literature summary for 1.1.1.50 extracted from

  • Hastings, C.; Hansson, V.
    Kinetic properties of the soluble 3alpha-hydroxysteroid dehydrogenase from rat testis and epididymis (1981), J. Steroid Biochem., 14, 705-711.
    View publication on PubMed
Search for more literature for 1.1.1.50

Inhibitors

Inhibitors Comment Organism Structure
additional information steroids Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0007 0.00075 17beta-hydroxy-5beta-androstan-3-one testis Rattus norvegicus
0.0012 0.0017 17beta-hydroxy-5beta-androstan-3-one also in this range: 5beta-dihydrotestosterone, rat epididymis Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NAD(P)H + H+ Rattus norvegicus discussion of physiological role 5alpha-androstane-3alpha,17beta-diol + NAD(P)+
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NAD(P)H + H+ i.e. 5alpha-androstan-17beta-ol-3-one Rattus norvegicus 5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
 r
5alpha-dihydrotestosterone + NAD(P)H + H+ i.e. 5alpha-androstan-17beta-ol-3-one Rattus norvegicus (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+
-
 r
5alpha-dihydrotestosterone + NAD(P)H + H+ discussion of physiological role Rattus norvegicus 5alpha-androstane-3alpha,17beta-diol + NAD(P)+
-
 r
5beta-dihydrotestosterone + NAD(P)H
-
 Rattus norvegicus 5beta-androstan-3alpha,17beta-diol + NAD(P)+
-
 ?