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Literature summary for 1.1.1.49 extracted from
- The synthesis of N-benzoylindoles as inhibitors of rat erythrocyte glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase (2018), J. Biochem. Mol. Toxicol., 32, e22193 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1-(1-(4-chlorophenyl)-2-nitroethyl)-1H-indole | - |
Rattus norvegicus | |
| 1-(1-(furan-2-yl)-2-nitroethyl)-1H-indole | - |
Rattus norvegicus | |
| 1-(2-nitro-1-phenylethyl)-1H-indole | - |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1H-indol-1-yl)(furan-2-yl)methanone | noncompetitive inhibitor | Rattus norvegicus |  |
| (1H-indol-1-yl)(tiyophen-2-yl)methanone | competitive inhibitor | Rattus norvegicus | |
| 1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole | competitive inhibitor | Rattus norvegicus | |
| N-(4-chlorobenzoyl)-indole | competitive inhibitor | Rattus norvegicus | |
| N-benzoylindole | noncompetitive inhibitor | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate + NADP+ | Rattus norvegicus | - |
6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P05370 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate + NADP+ | - |
Rattus norvegicus | 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G6PD | - |
Rattus norvegicus |
| glucose-6-phosphate dehydrogenase | - |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0026 | - |
N-(4-chlorobenzoyl)-indole | pH 8, 25°C | Rattus norvegicus | |
| 0.0026 | - |
(1H-indol-1-yl)(tiyophen-2-yl)methanone | pH 8, 25°C | Rattus norvegicus | |
| 0.093 | - |
N-benzoylindole | pH 8, 25°C | Rattus norvegicus | |
| 0.23 | - |
(1H-indol-1-yl)(furan-2-yl)methanone | pH 8, 25°C | Rattus norvegicus | |
| 0.483 | - |
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole | pH 8, 25°C | Rattus norvegicus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0034 | - |
pH 8, 25°C | Rattus norvegicus | N-(4-chlorobenzoyl)-indole | |
| 0.0039 | - |
pH 8, 25°C | Rattus norvegicus | (1H-indol-1-yl)(tiyophen-2-yl)methanone | |
| 0.087 | - |
pH 8, 25°C | Rattus norvegicus | N-benzoylindole | |
| 0.173 | - |
pH 8, 25°C | Rattus norvegicus | (1H-indol-1-yl)(furan-2-yl)methanone | |
| 1.5 | - |
pH 8, 25°C | Rattus norvegicus | 1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays an important function in various biochemical processes as it generates reducing power of the cell | Rattus norvegicus |
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