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Literature summary for 1.1.1.49 extracted from

  • De la Rosa, A.; Gomez-Cabrera, M.; Vinue, A.; Gonzalez-Navarro, H.; Sanchez-Andres, J.; Vina, J.
    Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life (2021), Free Radic. Biol. Med., 164, 149-153 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NADP+ Mus musculus
-
6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic beta cell moderate overexpression of the enzyme (G6PD) can protect beta-cells from age-associated oxidative stress thus reducing the risk of developing type 2 diabetes. The animal show an improved glucose tolerance and insulin sensitivity when compared to old age-matched wild type ones Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+
-
Mus musculus 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
G6PD
-
Mus musculus
glucose-6-phosphate dehydrogenase
-
Mus musculus

General Information

General Information Comment Organism
metabolism moderate overexpression of the enzyme (G6PD) can protect beta-cells from age-associated oxidative stress thus reducing the risk of developing type 2 diabetes Mus musculus
physiological function critical enzyme to provide NADPH Mus musculus