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Literature summary for 1.1.1.49 extracted from

  • Tome, M.E.; Johnson, D.B.; Samulitis, B.K.; Dorr, R.T.; Briehl, M.M.
    Glucose 6-phosphate dehydrogenase overexpression models glucose deprivation and sensitizes lymphoma cells to apoptosis (2006), Antioxid. Redox Signal., 8, 1315-1327.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in WEHI7.2 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information stable overexpression in WEHI7.2 murine thymic lymphoma cells models glucose deprivation and sensitizes lymphoma cells to dexamethasone-induced apoptosis, overview, G6PDH-overexpressing WEHI7.2 cells are more sensitive to oxidative stress and glucocorticoids Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NADP+ Mus musculus G6PDH is the rate-limiting step in the formation of NADPH via the triphosphate, and is responsible for the major supply of NADPH in the cell D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
WEHI7.2 cell murine thymic lymphoma cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+
-
Mus musculus D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?
D-glucose 6-phosphate + NADP+ G6PDH is the rate-limiting step in the formation of NADPH via the triphosphate, and is responsible for the major supply of NADPH in the cell Mus musculus D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
G6PD
-
Mus musculus
glucose 6-phosphate dehydrogenase
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Mus musculus