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Literature summary for 1.1.1.45 extracted from
- L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis (1964), Acta Biochim. Pol., 9, 269-277.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetate | - |
Schwanniomyces occidentalis |  |
| p-chloromercuribenzoate | - |
Schwanniomyces occidentalis | |
| Phenylmercurinitrate | - |
Schwanniomyces occidentalis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
NAD+ | cosubstrate L-gulonate, pH 7.5 and pH 8.5 | Schwanniomyces occidentalis | |
| 19 | - |
D-gluconate | cofactor NAD+, pH 8.5 | Schwanniomyces occidentalis | |
| 55 | - |
L-gulonate | cofactor NAD+, pH 8.5 | Schwanniomyces occidentalis | |
| 67 | - |
L-gulonate | cofactor NAD+, pH 7.5 | Schwanniomyces occidentalis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-gulonic acid + NAD+ | Schwanniomyces occidentalis | glucuronate-xylulose cycle | 3-dehydro-L-gulonic acid + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schwanniomyces occidentalis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 67% yield | Schwanniomyces occidentalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-gluconic acid + NAD+ | - |
Schwanniomyces occidentalis | ? | - |
? | |
| D-lyxonic acid + NAD+ | - |
Schwanniomyces occidentalis | ? | - |
? | |
| L-gulonic acid + NAD+ | stereospecificity for L-configuration of the beta-carbon hydroxyl group | Schwanniomyces occidentalis | 3-dehydro-L-gulonic acid + NADH + H+ | - |
r | |
| L-gulonic acid + NAD+ | glucuronate-xylulose cycle | Schwanniomyces occidentalis | 3-dehydro-L-gulonic acid + NADH + H+ | - |
? | |
| L-idonic acid + NAD+ | - |
Schwanniomyces occidentalis | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
in solution instable, by addition of below mM of cyanide several days in the cold, minor effect through EDTA-addition | Schwanniomyces occidentalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
oxidation of L-gulonic acid | Schwanniomyces occidentalis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Schwanniomyces occidentalis | |
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Release 2023.1 (January 2023)
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