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Literature summary for 1.1.1.44 extracted from

  • Corkins, M.E.; Wilson, S.; Cocuron, J.C.; Alonso, A.P.; Bird, A.J.
    The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast (2017), J. Biol. Chem., 292, 13823-13832 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.44

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Schizosaccharomyces pombe 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
6-phospho-D-gluconate + NADP+ Schizosaccharomyces pombe ATCC 24843 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe P78812 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-
Schizosaccharomyces pombe ATCC 24843 P78812 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-

Purification (Commentary)

Purification (Comment) Organism
-
 Schizosaccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Schizosaccharomyces pombe D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
6-phospho-D-gluconate + NADP+ 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
6-phospho-D-gluconate + NADP+
-
 Schizosaccharomyces pombe ATCC 24843 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
6-phospho-D-gluconate + NADP+ 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe ATCC 24843 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase 1
-
 Schizosaccharomyces pombe
GCG1
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
metabolism 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe