Literature summary for 1.1.1.44 extracted from

Gonul Baltaci, N.; Guler, C.; Ceylan, H.; Kalin, S.N.; Adem, S.; Kocpinar, E.F.; Erdogan, O.; Budak, H.
In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen (2018), J. Biochem. Mol. Toxicol., 2018, e22229 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Fe3+	noncompetitive inhibition with respect to NADP+ and competitive inhibition with respect to 6-phospho-D-gluconate	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
120000	-	gel filtration	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	Rattus norvegicus	-	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P85968	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
15	-	pH 7.6, and temperature not specified in the publication	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	-	Rattus norvegicus	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 59000, SDS-PAGE	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
6-phosphogluconate dehydrogenase	-	Rattus norvegicus
6PGD	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.186	-	Fe3+	pH 7.6, and temperature not specified in the publication, noncompetitive inhibition with respect to NADP+	Rattus norvegicus
0.223	-	Fe3+	pH 7.6, and temperature not specified in the publication, competitive inhibition with respect to 6-phospho-D-gluconate	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.225	-	pH 7.6, and temperature not specified in the publication	Rattus norvegicus	Fe3+

Expression

Organism	Comment	Expression
Rattus norvegicus	gene expressions is significantly repressed in the presence of nontoxic (0.87 and 3 ppm) and toxic iron concentrations (30 and 300 ppm)	down

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Release 2023.1 (January 2023)