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Literature summary for 1.1.1.44 extracted from

  • Daneshmandi, S.; Cassel, T.; Lin, P.; Higashi, R.M.; Wulf, G.M.; Boussiotis, V.A.; Fan, T.W.; Seth, P.
    Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector Tcells with enhanced anti-tumor function (2021), Cell Rep., 34, 108831 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.44

Inhibitors

Inhibitors Comment Organism Structure
6-aminonicotinamide
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Mus musculus the enzyme is involved in the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9DCD0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte from spleen, lymph node or thymus Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Mus musculus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
6-phospho-D-gluconate + NADP+ the enzyme is involved in the oxidative pentose phosphate pathway Mus musculus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
 Mus musculus
6PGD
-
 Mus musculus

General Information

General Information Comment Organism
drug target blockade of 6-phosphogluconate dehydrogenase reprograms CD8+ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies Mus musculus
malfunction blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function Mus musculus
metabolism the enzyme is involved in the oxidative pentose phosphate pathway Mus musculus
physiological function the enzyme is a modulator of CD8+ T cell activation and differentiation Mus musculus