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Literature summary for 1.1.1.44 extracted from

  • Polat, I.H.; Tarrado-Castellarnau, M.; Bharat, R.; Perarnau, J.; Benito, A.; Cortes, R.; Sabatier, P.; Cascante, M.
    Oxidative pentose phosphate pathway enzyme 6-phosphogluconate dehydrogenase plays a key role in breast cancer metabolism (2021), Biology, 10, 85 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-hydroxy-8-methoxy-anthraquinone inhibition of the enzyme (6PGD) via chemical inhibitor 1-hydroxy-8-methoxy-anthraquinone results in an induction of senescence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P52209
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
Homo sapiens
6PGD
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens

General Information

General Information Comment Organism
drug target the enzyme (6PGD) is a putative therapeutic drug target in breast cancer treatment. Targeting 6PGD not only reduces cell proliferation through cell cycle arrest and apoptosis induction but also activates p53 and decreases the stem cell-like characteristics of breast cancer cells. Inhibition of 6PGD alters the stem cell characteristics and mammosphere formation capabilities of MCF-7 cells, opening new avenues to prevent cancer recurrance after surgery or chemotherapy. Inhibition of 6PGD via chemical inhibitor 1-hydroxy-8-methoxy-anthraquinone results in an induction of senescence, which, together with the cell cycle arrest and apoptosis induction, might be orchestrated by p53 activation Homo sapiens
metabolism inhibition of the enzyme (6PGD) in MCF-7 cells reduces cell proliferation and shows a significant decrease in glucose consumption and an increase in glutamine consumption, resulting in an important alteration in the metabolism of these cells Homo sapiens
metabolism no difference in reactive oxygen species production levels is observed after inhibition of the enzyme (6PGD), indicating that 6PGD, in contrast to glucose 6-phosphate dehydrogenase, is not involved in redox balance Homo sapiens
metabolism the enzyme plays a key role in breast cancer metabolism Homo sapiens
physiological function the enzyme is involved in the oxidative branch of the pentose phosphate pathway Homo sapiens