Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1H-indol-1-yl(tiyophen-2-yl) methanon | - |
Homo sapiens | |
N-(4-chlorobenzoyl)-indole | - |
Homo sapiens | |
N-benzoylindole | - |
Homo sapiens | |
physcion | 1,8-dihydroxy-3-methoxy-6-methyl-anthrachinon | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | Homo sapiens | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52209 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | hyperactivation is mediated through post-transcriptional and post-translational modifications by YTH domain family 2 (YTHDF2), Nrf2 (nuclear factor erythroid 2-related factor 2), EGFR (epidermal growth factor receptor) and via direct structural interactions with ME1 (malic enzyme 1) | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | monomers act independently to each other. Each monomer consists of large alpha-helical domain while small beta-alpha-beta domain, forming a six stranded beta-sheet | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Homo sapiens |
6PGD | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | overexpressed in number of cancer types. Upregulated expression of the enzyme (6PGD) provides metabolic as well as defensive advantage to cancer cells, thus, promoting their proliferative and metastatic potential. Enhanced 6PGD expression also performs key role in development of chemoresistance as well as radiation resistance in cancer | up |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme might serve as promising therapeutic target for the treatment of cancers in which the enzyme (6PGD) is aberrantly overexpressed | Homo sapiens |