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Literature summary for 1.1.1.44 extracted from

  • Pasti, C.; Rinaldi, E.; Cervellati, C.; Dallocchio, F.; Hardre, R.; Salmon, L.; Hanau, S.
    Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei (2003), Bioorg. Med. Chem., 11, 1207-1214.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
1,5-diphospho-D-ribulose
-
Ovis aries
1,5-diphospho-D-ribulose
-
Trypanosoma brucei
1,5-diphospho-ribitol
-
Ovis aries
1,5-diphospho-ribitol
-
Trypanosoma brucei
2-deoxy-6-phosphono-D-gluconate
-
Ovis aries
2-deoxy-6-phosphono-D-gluconate
-
Trypanosoma brucei
4-phospho-D-erythronate bio-isosteric analogue Ovis aries
4-phospho-D-erythronate bio-isosteric analogue Trypanosoma brucei
4-phospho-D-erythrose bio-isosteric analogue Ovis aries
4-phospho-D-erythrose bio-isosteric analogue Trypanosoma brucei
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
Ovis aries
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
Trypanosoma brucei
5-deoxy-5-phosphonoD-arabinonate
-
Ovis aries
5-deoxy-5-phosphonoD-arabinonate
-
Trypanosoma brucei
5-phospho-D-arabinonamide
-
Ovis aries
5-phospho-D-arabinonamide
-
Trypanosoma brucei
5-phospho-D-arabinonate
-
Ovis aries
5-phospho-D-arabinonate
-
Trypanosoma brucei
5-phospho-D-arabinonhydrazide
-
Ovis aries
5-phospho-D-arabinonhydrazide
-
Trypanosoma brucei
5-phospho-D-arabinono-1,4-lactone
-
Ovis aries
5-phospho-D-arabinono-1,4-lactone
-
Trypanosoma brucei
5-phospho-D-arabinonohydroxamic acid
-
Ovis aries
5-phospho-D-arabinonohydroxamic acid
-
Trypanosoma brucei
5-phospho-D-arabinose
-
Ovis aries
5-phospho-D-arabinose
-
Trypanosoma brucei
5-phospho-D-ribonate
-
Ovis aries
5-phospho-D-ribonate
-
Trypanosoma brucei
6-deoxy-6-phosphono-D-gluconate
-
Ovis aries
6-deoxy-6-phosphono-D-gluconate
-
Trypanosoma brucei
6-phospho-D-galactonate
-
Ovis aries
6-phospho-D-galactonate
-
Trypanosoma brucei
6-phosphono-D-mannonate competitive Ovis aries
6-phosphono-D-mannonate competitive Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0048
-
6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Trypanosoma brucei
0.0053
-
6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei
0.011
-
6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Ovis aries
0.03
-
6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries P00349
-
-
Trypanosoma brucei P31072
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from Escherichia coli Trypanosoma brucei

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-keto-6-phospho-D-gluconate via 1,2-enediol intermediate Ovis aries D-ribulose 5-phosphate + CO2
-
?
3-keto-6-phospho-D-gluconate via 1,2-enediol intermediate Trypanosoma brucei D-ribulose 5-phosphate + CO2
-
?
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
-
Ovis aries ?
-
?
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
-
Trypanosoma brucei ?
-
?
6-phospho-D-gluconate + NADP+ overall reaction Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
6-phospho-D-gluconate + NADP+ overall reaction Trypanosoma brucei D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
6-phospho-D-gluconate + NADP+
-
Ovis aries 3-keto-6-phospho-D-gluconate + NADPH + H+
-
?
6-phospho-D-gluconate + NADP+
-
Trypanosoma brucei 3-keto-6-phospho-D-gluconate + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
Ovis aries
6-phosphogluconate dehydrogenase
-
Trypanosoma brucei
6PGDH
-
Ovis aries
6PGDH
-
Trypanosoma brucei

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
assay at Ovis aries
20
-
assay at Trypanosoma brucei

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.53
-
6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Ovis aries
1.4
-
6,7-dideoxy-7-phosphono-D-glucoheptonate pH 8.0, 20°C Trypanosoma brucei
9
-
6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries
31.8
-
6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Ovis aries
8
-
assay at Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Ovis aries
NADP+
-
Trypanosoma brucei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00013
-
4-phospho-D-erythronate pH 8.0, 20°C Trypanosoma brucei
0.00095
-
5-phospho-D-ribonate pH 8.0, 20°C Trypanosoma brucei
0.0013
-
6-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei
0.0034
-
5-phospho-D-arabinonate pH 8.0, 20°C Trypanosoma brucei
0.0044
-
2-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Trypanosoma brucei
0.0056
-
5-phospho-D-arabinonamide pH 8.0, 20°C Trypanosoma brucei
0.0058
-
5-phospho-D-arabinonohydroxamic acid pH 8.0, 20°C Trypanosoma brucei
0.007
-
5-deoxy-5-phosphonoD-arabinonate pH 8.0, 20°C Trypanosoma brucei
0.011
-
4-phospho-D-erythronate pH 8.0, 20°C Ovis aries
0.011
-
5-phospho-D-arabinono-1,4-lactone pH 8.0, 20°C Trypanosoma brucei
0.0212
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate pH 8.0, 20°C Trypanosoma brucei
0.025
-
5-phospho-D-arabinose pH 8.0, 20°C Trypanosoma brucei
0.0267
-
5-phospho-D-arabinonhydrazide pH 8.0, 20°C Trypanosoma brucei
0.0358
-
6-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries
0.067
-
5-phospho-D-ribonate pH 8.0, 20°C Ovis aries
0.0803
-
5-phospho-D-arabinonamide pH 8.0, 20°C Ovis aries
0.109
-
5-phospho-D-arabinonate pH 8.0, 20°C Ovis aries
0.122
-
1,5-diphospho-ribitol pH 8.0, 20°C Trypanosoma brucei
0.128
-
5-phospho-D-arabinonhydrazide pH 8.0, 20°C Ovis aries
0.135
-
6-phosphono-D-mannonate pH 8.0, 20°C Ovis aries
0.147
-
5-phospho-D-arabinono-1,4-lactone pH 8.0, 20°C Ovis aries
0.175
-
4-phospho-D-erythrose pH 8.0, 20°C Trypanosoma brucei
0.19
-
6-phospho-D-galactonate pH 8.0, 20°C Trypanosoma brucei
0.274
-
1,5-diphospho-D-ribulose pH 8.0, 20°C Trypanosoma brucei
0.307
-
5-phospho-D-arabinonohydroxamic acid pH 8.0, 20°C Ovis aries
0.433
-
5-deoxy-5-phosphonoD-arabinonate pH 8.0, 20°C Ovis aries
0.5
-
1,5-diphospho-ribitol pH 8.0, 20°C Ovis aries
0.565
-
6-phospho-D-galactonate pH 8.0, 20°C Ovis aries
0.71
-
5-phospho-D-arabinose pH 8.0, 20°C Ovis aries
0.77
-
2-deoxy-6-phosphono-D-gluconate pH 8.0, 20°C Ovis aries
0.8
-
6-phosphono-D-mannonate pH 8.0, 20°C Trypanosoma brucei
1
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate pH 8.0, 20°C Ovis aries
1
-
1,5-diphospho-D-ribulose pH 8.0, 20°C Ovis aries
1.59
-
4-phospho-D-erythrose pH 8.0, 20°C Ovis aries