Cloned (Comment) | Organism |
---|---|
overexpression in Escherichia coli | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,5-diphospho-D-ribulose | - |
Ovis aries | |
1,5-diphospho-D-ribulose | - |
Trypanosoma brucei | |
1,5-diphospho-ribitol | - |
Ovis aries | |
1,5-diphospho-ribitol | - |
Trypanosoma brucei | |
2-deoxy-6-phosphono-D-gluconate | - |
Ovis aries | |
2-deoxy-6-phosphono-D-gluconate | - |
Trypanosoma brucei | |
4-phospho-D-erythronate | bio-isosteric analogue | Ovis aries | |
4-phospho-D-erythronate | bio-isosteric analogue | Trypanosoma brucei | |
4-phospho-D-erythrose | bio-isosteric analogue | Ovis aries | |
4-phospho-D-erythrose | bio-isosteric analogue | Trypanosoma brucei | |
5,6-dideoxy-6-phosphono-D-arabino-hexonate | - |
Ovis aries | |
5,6-dideoxy-6-phosphono-D-arabino-hexonate | - |
Trypanosoma brucei | |
5-deoxy-5-phosphonoD-arabinonate | - |
Ovis aries | |
5-deoxy-5-phosphonoD-arabinonate | - |
Trypanosoma brucei | |
5-phospho-D-arabinonamide | - |
Ovis aries | |
5-phospho-D-arabinonamide | - |
Trypanosoma brucei | |
5-phospho-D-arabinonate | - |
Ovis aries | |
5-phospho-D-arabinonate | - |
Trypanosoma brucei | |
5-phospho-D-arabinonhydrazide | - |
Ovis aries | |
5-phospho-D-arabinonhydrazide | - |
Trypanosoma brucei | |
5-phospho-D-arabinono-1,4-lactone | - |
Ovis aries | |
5-phospho-D-arabinono-1,4-lactone | - |
Trypanosoma brucei | |
5-phospho-D-arabinonohydroxamic acid | - |
Ovis aries | |
5-phospho-D-arabinonohydroxamic acid | - |
Trypanosoma brucei | |
5-phospho-D-arabinose | - |
Ovis aries | |
5-phospho-D-arabinose | - |
Trypanosoma brucei | |
5-phospho-D-ribonate | - |
Ovis aries | |
5-phospho-D-ribonate | - |
Trypanosoma brucei | |
6-deoxy-6-phosphono-D-gluconate | - |
Ovis aries | |
6-deoxy-6-phosphono-D-gluconate | - |
Trypanosoma brucei | |
6-phospho-D-galactonate | - |
Ovis aries | |
6-phospho-D-galactonate | - |
Trypanosoma brucei | |
6-phosphono-D-mannonate | competitive | Ovis aries | |
6-phosphono-D-mannonate | competitive | Trypanosoma brucei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0048 | - |
6,7-dideoxy-7-phosphono-D-glucoheptonate | pH 8.0, 20°C | Trypanosoma brucei | |
0.0053 | - |
6-phosphono-D-gluconate | pH 8.0, 20°C | Trypanosoma brucei | |
0.011 | - |
6,7-dideoxy-7-phosphono-D-glucoheptonate | pH 8.0, 20°C | Ovis aries | |
0.03 | - |
6-phosphono-D-gluconate | pH 8.0, 20°C | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | P00349 | - |
- |
Trypanosoma brucei | P31072 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant from Escherichia coli | Trypanosoma brucei |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-keto-6-phospho-D-gluconate | via 1,2-enediol intermediate | Ovis aries | D-ribulose 5-phosphate + CO2 | - |
? | |
3-keto-6-phospho-D-gluconate | via 1,2-enediol intermediate | Trypanosoma brucei | D-ribulose 5-phosphate + CO2 | - |
? | |
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+ | - |
Ovis aries | ? | - |
? | |
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+ | - |
Trypanosoma brucei | ? | - |
? | |
6-phospho-D-gluconate + NADP+ | overall reaction | Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | overall reaction | Trypanosoma brucei | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | - |
Ovis aries | 3-keto-6-phospho-D-gluconate + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | - |
Trypanosoma brucei | 3-keto-6-phospho-D-gluconate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Ovis aries |
6-phosphogluconate dehydrogenase | - |
Trypanosoma brucei |
6PGDH | - |
Ovis aries |
6PGDH | - |
Trypanosoma brucei |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Ovis aries |
20 | - |
assay at | Trypanosoma brucei |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.53 | - |
6,7-dideoxy-7-phosphono-D-glucoheptonate | pH 8.0, 20°C | Ovis aries | |
1.4 | - |
6,7-dideoxy-7-phosphono-D-glucoheptonate | pH 8.0, 20°C | Trypanosoma brucei | |
9 | - |
6-phosphono-D-gluconate | pH 8.0, 20°C | Ovis aries | |
31.8 | - |
6-phosphono-D-gluconate | pH 8.0, 20°C | Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Ovis aries |
8 | - |
assay at | Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Ovis aries | |
NADP+ | - |
Trypanosoma brucei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
4-phospho-D-erythronate | pH 8.0, 20°C | Trypanosoma brucei | |
0.00095 | - |
5-phospho-D-ribonate | pH 8.0, 20°C | Trypanosoma brucei | |
0.0013 | - |
6-deoxy-6-phosphono-D-gluconate | pH 8.0, 20°C | Trypanosoma brucei | |
0.0034 | - |
5-phospho-D-arabinonate | pH 8.0, 20°C | Trypanosoma brucei | |
0.0044 | - |
2-deoxy-6-phosphono-D-gluconate | pH 8.0, 20°C | Trypanosoma brucei | |
0.0056 | - |
5-phospho-D-arabinonamide | pH 8.0, 20°C | Trypanosoma brucei | |
0.0058 | - |
5-phospho-D-arabinonohydroxamic acid | pH 8.0, 20°C | Trypanosoma brucei | |
0.007 | - |
5-deoxy-5-phosphonoD-arabinonate | pH 8.0, 20°C | Trypanosoma brucei | |
0.011 | - |
4-phospho-D-erythronate | pH 8.0, 20°C | Ovis aries | |
0.011 | - |
5-phospho-D-arabinono-1,4-lactone | pH 8.0, 20°C | Trypanosoma brucei | |
0.0212 | - |
5,6-dideoxy-6-phosphono-D-arabino-hexonate | pH 8.0, 20°C | Trypanosoma brucei | |
0.025 | - |
5-phospho-D-arabinose | pH 8.0, 20°C | Trypanosoma brucei | |
0.0267 | - |
5-phospho-D-arabinonhydrazide | pH 8.0, 20°C | Trypanosoma brucei | |
0.0358 | - |
6-deoxy-6-phosphono-D-gluconate | pH 8.0, 20°C | Ovis aries | |
0.067 | - |
5-phospho-D-ribonate | pH 8.0, 20°C | Ovis aries | |
0.0803 | - |
5-phospho-D-arabinonamide | pH 8.0, 20°C | Ovis aries | |
0.109 | - |
5-phospho-D-arabinonate | pH 8.0, 20°C | Ovis aries | |
0.122 | - |
1,5-diphospho-ribitol | pH 8.0, 20°C | Trypanosoma brucei | |
0.128 | - |
5-phospho-D-arabinonhydrazide | pH 8.0, 20°C | Ovis aries | |
0.135 | - |
6-phosphono-D-mannonate | pH 8.0, 20°C | Ovis aries | |
0.147 | - |
5-phospho-D-arabinono-1,4-lactone | pH 8.0, 20°C | Ovis aries | |
0.175 | - |
4-phospho-D-erythrose | pH 8.0, 20°C | Trypanosoma brucei | |
0.19 | - |
6-phospho-D-galactonate | pH 8.0, 20°C | Trypanosoma brucei | |
0.274 | - |
1,5-diphospho-D-ribulose | pH 8.0, 20°C | Trypanosoma brucei | |
0.307 | - |
5-phospho-D-arabinonohydroxamic acid | pH 8.0, 20°C | Ovis aries | |
0.433 | - |
5-deoxy-5-phosphonoD-arabinonate | pH 8.0, 20°C | Ovis aries | |
0.5 | - |
1,5-diphospho-ribitol | pH 8.0, 20°C | Ovis aries | |
0.565 | - |
6-phospho-D-galactonate | pH 8.0, 20°C | Ovis aries | |
0.71 | - |
5-phospho-D-arabinose | pH 8.0, 20°C | Ovis aries | |
0.77 | - |
2-deoxy-6-phosphono-D-gluconate | pH 8.0, 20°C | Ovis aries | |
0.8 | - |
6-phosphono-D-mannonate | pH 8.0, 20°C | Trypanosoma brucei | |
1 | - |
5,6-dideoxy-6-phosphono-D-arabino-hexonate | pH 8.0, 20°C | Ovis aries | |
1 | - |
1,5-diphospho-D-ribulose | pH 8.0, 20°C | Ovis aries | |
1.59 | - |
4-phospho-D-erythrose | pH 8.0, 20°C | Ovis aries |