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Literature summary for 1.1.1.44 extracted from
- A multiple role for the coenzyme in the mechanism of action of 6-phosphogluconate dehydrogenase (1973), J. Biol. Chem., 248, 4920-4925.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Cyberlindnera jadinii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-2-deoxyglucose | - |
Cyberlindnera jadinii |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
NADP+ | - |
Cyberlindnera jadinii | |
| 0.054 | - |
6-phosphogluconate | - |
Cyberlindnera jadinii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-gluconate + NADP+ | Cyberlindnera jadinii | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | Sus scrofa | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | Saccharomyces cerevisiae | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cyberlindnera jadinii | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-deoxy-6-phosphogluconate + NADP+ | oxidation, 1.5% activity of that of 6-phosphogluconate | Cyberlindnera jadinii | 3-oxo-2-deoxy-6-phosphogluconate + NADPH | - |
r | |
| 3-oxo-2-deoxy-6-phosphogluconate + NADP+ | decarboxylation | Cyberlindnera jadinii | 1-deoxyribulose 5-phosphate + CO2 + NADPH | - |
r | |
| 3-oxo-2-deoxy-6-phosphogluconate + NADPH | reduction | Cyberlindnera jadinii | 2-deoxy-6-phosphogluconate + NADP+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Cyberlindnera jadinii | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Sus scrofa | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Saccharomyces cerevisiae | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
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Release 2023.1 (January 2023)
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