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Literature summary for 1.1.1.43 extracted from
- Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study (2010), J. Enzyme Inhib. Med. Chem., 25, 476-479.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol | non-competitive inhibition | Homo sapiens |  |
| dacarbazine | non-competitive inhibition | Homo sapiens | |
| Furosemide | non-competitive inhibition | Homo sapiens | |
| gadopentetic acid | non-competitive inhibition | Homo sapiens | |
| ketotifen | non-competitive inhibition | Homo sapiens | |
| meloxicam | non-competitive inhibition | Homo sapiens | |
| methotrexate | non-competitive inhibition | Homo sapiens | |
| metochloropramide | non-competitive inhibition | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purified 2256times in a yield of 44.22% by using ammonium sulfate precipitation and 2', 5'-ADP Sepharose 4B affinity gel. Temperature of +4°C is maintained during the purification process | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | 6-phospho-2-dehydro-D-gluconate + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6PGDH | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
metochloropramide | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
| 0.006 | - |
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
| 0.008 | - |
ketotifen | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
| 0.01 | - |
dacarbazine | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
| 0.05 | - |
meloxicam | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
| 0.0734 | - |
gadopentetic acid | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
| 0.127 | - |
Furosemide | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
| 0.136 | - |
methotrexate | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | ketotifen | |
| 0.01 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | dacarbazine | |
| 0.05 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | meloxicam | |
| 0.125 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | Furosemide | |
| 0.142 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | methotrexate | |
| 3.27 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | metochloropramide | |
| 3.66 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol | |
| 209 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | gadopentetic acid | |
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