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Literature summary for 1.1.1.423 extracted from

  • Shanati, T.; Ansorge-Schumacher, M.B.
    Biodegradation of ephedrine isomers by Arthrobacter sp. strain TS-15 discovery of novel ephedrine and pseudoephedrine dehydrogenases (2020), Appl. Environ. Microbiol., 86, e02487-19 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.423

Inhibitors

Inhibitors Comment Organism Structure
(R,R)-(-)-pseudoephedrine higher substrate inhibition Arthrobacter sp. TS-15
(R,S)-(-)-ephedrine substrate inhibition Arthrobacter sp. TS-15

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
 NAD+ pH 7.8, 25°C Arthrobacter sp. TS-15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(-)-(1R,2S)-ephedrine + NAD+ Arthrobacter sp. TS-15
-
 (S)-2-methylamino-1-phenylpropan-1-one + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Arthrobacter sp. TS-15 A0A545BBR2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-(1R,2S)-ephedrine + NAD+
-
 Arthrobacter sp. TS-15 (S)-2-methylamino-1-phenylpropan-1-one + NADH + H+
-
 ?
(-)-(1R,2S)-ephedrine + NAD+ the enzyme exhibits a strict enantioselectivity for the oxidation of (-)-(1R,2S)-ephedrine and (R,R)-(-)-pseudoephedrine Arthrobacter sp. TS-15 (S)-2-methylamino-1-phenylpropan-1-one + NADH + H+
-
 ?
(R,R)-(-)-pseudoephedrine + NAD+ the enzyme exhibits a strict enantioselectivity for the oxidation of (-)-(1R,2S)-ephedrine and (R,R)-(-)-pseudoephedrine Arthrobacter sp. TS-15 ? + NADH + H+
-
 ?
additional information no activity on (S,N)-(+)-(pseudo)ephedrine or (R,N)-(-)-(pseudo)ephedrine Arthrobacter sp. TS-15 ?
-
-

Synonyms

Synonyms Comment Organism
EDH
-
 Arthrobacter sp. TS-15

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Arthrobacter sp. TS-15

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.78
-
 (R,R)-(-)-pseudoephedrine pH 7.8, 25°C Arthrobacter sp. TS-15
4.61
-
 (R,S)-(-)-ephedrine pH 7.8, 25°C Arthrobacter sp. TS-15