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Literature summary for 1.1.1.42 extracted from

  • Lee, J.H.; Go, Y.; Kim, D.Y.; Lee, S.H.; Kim, O.H.; Jeon, Y.H.; Kwon, T.K.; Bae, J.H.; Song, D.K.; Rhyu, I.J.; Lee, I.K.; Shong, M.; Oh, B.C.; Petucci, C.; Park, J.W.; Osborne, T.F.; Im, S.S.
    Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue (2020), Exp. Mol. Med., 52, 238-252 .
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Mus musculus
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P54071
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-
brown adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
 Mus musculus 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
IDH2
-
 Mus musculus
isocitrate dehydrogenase 2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockout mice are more susceptible to high fat diet-induced obesity than wild type mice.Brown adipose tissue dysfunction in the enzyme knockout mice is due to mitochondrial dysfunction Mus musculus