Literature summary for 1.1.1.42 extracted from

Lee, S.M.; Park, S.Y.; Shin, S.W.; Kil, I.S.; Yang, E.S.; Park, J.W.
Silencing of cytosolic NADP(+)-dependent isocitrate dehydrogenase by small interfering RNA enhances the sensitivity of HeLa cells toward staurosporine (2009), Free Radic. Res., 43, 165-173.

Search for more literature for 1.1.1.42

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HeLa cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	transfection of HeLa cells with an IDPc small interfering RNA decreases activity of IDPc by 80%, enhancing the susceptibility of staurosporine-induced apoptosis reflected by DNA fragmentation, cellular redox status and the modulation of apoptotic marker proteins	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
isocitrate + NADP+	-	Homo sapiens	2-oxoglutarate + CO2 + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
cytosolic NADP(+)-dependent isocitrate dehydrogenase	-	Homo sapiens
ICDH	-	Homo sapiens
IDPc	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens

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Release 2023.1 (January 2023)