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Literature summary for 1.1.1.42 extracted from

  • Kil, I.S.; Shin, S.W.; Yeo, H.S.; Lee, Y.S.; Park, J.W.
    Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis (2006), Mol. Pharmacol., 70, 1053-1061.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ coadministration with oxalomalate results in inhibition of enzyme and glutaredoxin and enhanced susceptibility to apoptosis Mus musculus
Cd2+ binds to C379 of enzyme, resulting in loss of activity and structural alterations. Loss of glutaredoxin activity in cells treated with Cd2+ is more pronounced when cells are transfected with enzyme antisense cDNA Sus scrofa
Oxalomalate competitive, coadministration with CD2+ results in inhibition of enzyme and glutaredoxin and enhanced susceptibility to apoptosis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-
mitochondrion
-
Sus scrofa 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
heart
-
Sus scrofa
-