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Literature summary for 1.1.1.42 extracted from

  • Steen, I.H.; Lien.T.; Birkeland, N-K.
    Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus (1997), Arch. MIcrobiol., 168, 412-420.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
NADP+
-
Archaeoglobus fulgidus
0.118
-
D,L-isocitrate
-
Archaeoglobus fulgidus
5.4
-
NAD+
-
Archaeoglobus fulgidus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for divalent cations Archaeoglobus fulgidus
Mn2+ absolute requirement for divalent cations Archaeoglobus fulgidus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
alpha2, 2 * 42000, SDS-PAGE Archaeoglobus fulgidus
80000
-
gel filtration Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Archaeoglobus fulgidus
-
2-oxoglutarate + NADPH + H+ + CO2
-
?

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus O29610
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Archaeoglobus fulgidus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
141
-
-
Archaeoglobus fulgidus

Storage Stability

Storage Stability Organism
4°C, several months, under oxic conditions Archaeoglobus fulgidus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
Archaeoglobus fulgidus 2-oxoglutarate + CO2 + NADH + H+
-
r
isocitrate + NADP+
-
Archaeoglobus fulgidus 2-oxoglutarate + NADPH + H+ + CO2
-
?

Subunits

Subunits Comment Organism
dimer alpha2, 2 * 42000, SDS-PAGE Archaeoglobus fulgidus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
90
-
-
Archaeoglobus fulgidus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
90
-
half life of 22 min in 50 mM tricine-KOH buffer, pH 8 Archaeoglobus fulgidus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6
-
-
Archaeoglobus fulgidus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Archaeoglobus fulgidus
NADP+
-
Archaeoglobus fulgidus