BRENDA - Enzyme Database
show all sequences of 1.1.1.410

Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars

Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.; Proc. Natl. Acad. Sci. USA 113, E4161-E4169 (2016)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.59
-
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
Cupriavidus necator
2.4
-
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
Cupriavidus necator
Organism
Organism
UniProt
Commentary
Textmining
Cupriavidus necator
Q0KBD2
-
-
Cupriavidus necator DSM 428
Q0KBD2
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
D-erythronate + NAD+
-
741345
Cupriavidus necator
2-dehydro-D-erythronate + NADH + H+
-
-
-
?
D-erythronate + NAD+
-
741345
Cupriavidus necator DSM 428
2-dehydro-D-erythronate + NADH + H+
-
-
-
?
D-erythronate + NADP+
-
741345
Cupriavidus necator
2-dehydro-D-erythronate + NADPH + H+
-
-
-
?
D-erythronate + NADP+
-
741345
Cupriavidus necator DSM 428
2-dehydro-D-erythronate + NADPH + H+
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
D-erythronate 2-dehydrogenase
-
Cupriavidus necator
denD
-
Cupriavidus necator
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3
-
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
Cupriavidus necator
19
-
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
Cupriavidus necator
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
NAD+ is preferred over NADP+
Cupriavidus necator
NADP+
NAD+ is preferred over NADP+
Cupriavidus necator
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
NAD+ is preferred over NADP+
Cupriavidus necator
NADP+
NAD+ is preferred over NADP+
Cupriavidus necator
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.59
-
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
Cupriavidus necator
2.4
-
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
Cupriavidus necator
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
D-erythronate + NAD+
-
741345
Cupriavidus necator
2-dehydro-D-erythronate + NADH + H+
-
-
-
?
D-erythronate + NAD+
-
741345
Cupriavidus necator DSM 428
2-dehydro-D-erythronate + NADH + H+
-
-
-
?
D-erythronate + NADP+
-
741345
Cupriavidus necator
2-dehydro-D-erythronate + NADPH + H+
-
-
-
?
D-erythronate + NADP+
-
741345
Cupriavidus necator DSM 428
2-dehydro-D-erythronate + NADPH + H+
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3
-
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
Cupriavidus necator
19
-
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
Cupriavidus necator
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.2
-
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
Cupriavidus necator
33
-
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
Cupriavidus necator
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.2
-
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
Cupriavidus necator
33
-
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
Cupriavidus necator
Other publictions for EC 1.1.1.410
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741345
Zhang
Assignment of function to a do ...
Cupriavidus necator, Cupriavidus necator DSM 428
Proc. Natl. Acad. Sci. USA
113
E4161-E4169
2016
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2
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2
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