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Literature summary for 1.1.1.4 extracted from

  • Gonzalez, E.; Fernandez, M.R.; Larroy, C.; Pares, X.; Biosca, J.A.
    Characterization and functional role of Saccharomyces cerevisiae 2,3-butanediol dehydrogenase (2001), Chem. Biol. Interact., 130, 425-434.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Saccharomyces cerevisiae Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
4-Methylpyrazole
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.055
-
NADH
-
Saccharomyces cerevisiae
0.55
-
NAD+
-
Saccharomyces cerevisiae
4.5
-
(3R,3S)-acetoin
-
Saccharomyces cerevisiae
14
-
(2R,3R)-2,3-butanediol
-
Saccharomyces cerevisiae
14.5
-
1-hydroxy-2-propanone
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R,3R)-2,3-butanediol + NAD+
-
Saccharomyces cerevisiae (3R)-acetoin + NADH
-
r
(3R,3S)-acetoin + NADH
-
Saccharomyces cerevisiae (2R,3R)-2,3-butanediol + meso-2,3-butanediol + NAD+
-
r
1-hydroxy-2-propanone + NADH + H+
-
Saccharomyces cerevisiae propane-1,2-diol + NAD+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
5 9
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+ no activity with NADP+ as cofactor Saccharomyces cerevisiae