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Literature summary for 1.1.1.39 extracted from

  • Day, D.A.; Neuburger, M.; Douce, R.
    Activation of NAD-linked malic enzyme in intact plant mitochondria by exogenous coenzyme A (1984), Arch. Biochem. Biophys., 231, 233-242.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
coenzyme A serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity Solanum tuberosum
coenzyme A serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity Brassica oleracea

Inhibitors

Inhibitors Comment Organism Structure
oxaloacetate
-
Brassica oleracea
oxaloacetate
-
Solanum tuberosum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Solanum tuberosum 5739
-
mitochondrion
-
Brassica oleracea 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Solanum tuberosum the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation ?
-
?
(S)-malate + NAD+ Brassica oleracea the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation ?
-
?

Organism

Organism UniProt Comment Textmining
Brassica oleracea
-
-
-
Solanum tuberosum
-
var. urgenta
-

Source Tissue

Source Tissue Comment Organism Textmining
bud
-
Solanum tuberosum
-
bud
-
Brassica oleracea
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+ the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation Solanum tuberosum ?
-
?
(S)-malate + NAD+ the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation Brassica oleracea ?
-
?
malate + NAD+
-
Solanum tuberosum pyruvate + CO2 + NADH + H+
-
?
malate + NAD+
-
Brassica oleracea pyruvate + CO2 + NADH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Solanum tuberosum
NAD+ cofactor Brassica oleracea