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Literature summary for 1.1.1.38 extracted from

  • Lee, W.; Ji, X.; Nissim, I.; Long, F.
    Malic enzyme couples mitochondria with aero32905773bic glycolysis in osteoblasts (2020), Cell Rep., 32, 108108 .
    View publication on PubMed
Search for more literature for 1.1.1.38

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Mus musculus
-
 pyruvate + CO2 + NADH + H+
-
 r
pyruvate + CO2 + NADH + H+ Mus musculus
-
 (S)-malate + NAD+
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus Q99KE1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Mus musculus pyruvate + CO2 + NADH + H+
-
 r
pyruvate + CO2 + NADH + H+
-
 Mus musculus (S)-malate + NAD+
-
 r

Synonyms

Synonyms Comment Organism
malic enzyme 2
-
 Mus musculus
ME2 mitochondrial NAD-dependent isoform of malic enzyme Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus
NADH
-
 Mus musculus

General Information

General Information Comment Organism
malfunction knockdown of isoform Me2 markedly reduces the glycolytic flux and impairs osteoblast proliferation and differentiation Mus musculus
metabolism isoform Me2 funnels glucose carbons into malate-aspartate shuttle to sustain glycolysis Mus musculus
physiological function the mitochondrial malic enzyme isoform Me2 functionally couples the mitochondria with aerobic glycolysis in osteoblasts Mus musculus