Activating Compound | Comment | Organism | Structure |
---|---|---|---|
fumarate | - |
Rattus norvegicus | |
fumarate | - |
Homo sapiens | |
fumarate | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Mus musculus | |
ATP | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23368 | - |
- |
Mus musculus | Q99KE1 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
INS-1 832/13 cell | - |
Rattus norvegicus | - |
insulinoma cell | - |
Rattus norvegicus | - |
insulinoma cell | - |
Homo sapiens | - |
insulinoma cell | - |
Mus musculus | - |
pancreatic islet | - |
Rattus norvegicus | - |
pancreatic islet | - |
Homo sapiens | - |
pancreatic islet | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NAD+ | - |
Rattus norvegicus | pyruvate + CO2 + NADH | - |
? | |
(S)-malate + NAD+ | - |
Homo sapiens | pyruvate + CO2 + NADH | - |
? | |
(S)-malate + NAD+ | - |
Mus musculus | pyruvate + CO2 + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mitochondrial malic enzyme ME2 | - |
Rattus norvegicus |
mitochondrial malic enzyme ME2 | - |
Homo sapiens |
mitochondrial malic enzyme ME2 | - |
Mus musculus |
mitochondrial NAD(P) malic enzyme ME2 | - |
Rattus norvegicus |
mitochondrial NAD(P) malic enzyme ME2 | - |
Homo sapiens |
mitochondrial NAD(P) malic enzyme ME2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ | Rattus norvegicus | |
NAD+ | dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ | Homo sapiens | |
NAD+ | dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ | Mus musculus |