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Literature summary for 1.1.1.38 extracted from

  • MacDonald, M.J.; Longacre, M.J.; Kendrick, M.A.
    Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells (2009), Arch. Biochem. Biophys., 488, 100-104.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
fumarate
-
Rattus norvegicus
fumarate
-
Homo sapiens
fumarate
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Mus musculus
ATP
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P23368
-
-
Mus musculus Q99KE1
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 832/13 cell
-
Rattus norvegicus
-
insulinoma cell
-
Rattus norvegicus
-
insulinoma cell
-
Homo sapiens
-
insulinoma cell
-
Mus musculus
-
pancreatic islet
-
Rattus norvegicus
-
pancreatic islet
-
Homo sapiens
-
pancreatic islet
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Rattus norvegicus pyruvate + CO2 + NADH
-
?
(S)-malate + NAD+
-
Homo sapiens pyruvate + CO2 + NADH
-
?
(S)-malate + NAD+
-
Mus musculus pyruvate + CO2 + NADH
-
?

Synonyms

Synonyms Comment Organism
mitochondrial malic enzyme ME2
-
Rattus norvegicus
mitochondrial malic enzyme ME2
-
Homo sapiens
mitochondrial malic enzyme ME2
-
Mus musculus
mitochondrial NAD(P) malic enzyme ME2
-
Rattus norvegicus
mitochondrial NAD(P) malic enzyme ME2
-
Homo sapiens
mitochondrial NAD(P) malic enzyme ME2
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+ dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ Rattus norvegicus
NAD+ dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ Homo sapiens
NAD+ dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ Mus musculus