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Literature summary for 1.1.1.370 extracted from

  • Kang, D.; Michon, C.; Morinaga, T.; Tanaka, K.; Takenaka, S.; Ishikawa, S.; Yoshida, K.
    Bacillus subtilis IolQ (DegA) is a transcriptional repressor of iolX encoding NAD+-dependent scyllo-inositol dehydrogenase (2017), BMC Microbiol., 17, 154 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene iolX Bacillus subtilis

Protein Variants

Protein Variants Comment Organism
additional information construction of an iolX disruption mutant strain BFS3018 from wild-type strain 168 Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
scyllo-inositol + NAD+ Bacillus subtilis
-
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
?
scyllo-inositol + NAD+ Bacillus subtilis 168
-
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis P40332
-
-
Bacillus subtilis 168 P40332
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
scyllo-inositol + NAD+
-
Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
?
scyllo-inositol + NAD+
-
Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
DegA
-
Bacillus subtilis
IolX
-
Bacillus subtilis
NAD+-dependent SI dehydrogenase
-
Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bacillus subtilis
NADH
-
Bacillus subtilis

Expression

Organism Comment Expression
Bacillus subtilis gene iolQ encodes a repressor of the iolX transcription, gene iolQ is organized in an operon immediately upstream of iolX, the repressor binds to the promoter region of iolX down
Bacillus subtilis myo- and scyllo-inositol are intracellular inducers of gene iolX, but they fail to antagonize DNA binding of IolQ in in vitro experiments up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the inositol metabolic pathway in Bacillus subtilis, organization of the relevant genes, overview Bacillus subtilis
physiological function Bacillus subtilis is able to utilize at least three inositol stereoisomers as carbon sources, myo-, scyllo-, and D-chiro-inositol (MI, SI, and DCI, respectively). NAD+-dependent SI dehydrogenase is responsible for SI catabolism. IolQ is a transcriptional repressor of iolX. Expression of gene iolQ is required to regulate gene iolX transcription in response to scyllo-inositol, identification of the two IolQ-binding sites within the iolX promoter region Bacillus subtilis