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Literature summary for 1.1.1.37 extracted from

  • Easlon, E.; Tsang, F.; Skinner, C.; Wang, C.; Lin, S.J.
    The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast (2008), Genes Dev., 22, 931-944.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.37

Protein Variants

Protein Variants Comment Organism
additional information isozyme Mdh1 overexpression in yeast extends life span of the organism requiring respiration and the Sir2 family, while the mdh1DELTAaat1DELTA double mutation blocks CR-mediated life span extension and also prevents the characteristic decrease in the NADH levels in the cytosolic/nuclear pool, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm Mdh2 Saccharomyces cerevisiae 5737
-
mitochondrion Mdh1, matrix Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Saccharomyces cerevisiae
-
 oxaloacetate + NADH + H+
-
 r
additional information Saccharomyces cerevisiae the malate-aspartate NADH shuttle components are metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast, the shuttle plays a major role in the activation of the downstream targets of calorie restriction such as Sir2, mechanism and regulation, detailed overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 This UniProt-ID has been deleted; isozyme Mdh1
-
Saccharomyces cerevisiae P22133 Mdh2; isozyme Mdh2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Saccharomyces cerevisiae oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+ mitochondrial isozyme Mdh1 preferably catalyzes the oxaloacetate formation, overview Saccharomyces cerevisiae oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+ the cytoplasmic isozyme Mdh2 catalyzes preferably the malate formation, overview Saccharomyces cerevisiae oxaloacetate + NADH + H+
-
 r
additional information the malate-aspartate NADH shuttle components are metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast, the shuttle plays a major role in the activation of the downstream targets of calorie restriction such as Sir2, mechanism and regulation, detailed overview Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
malate dehydrogenase
-
 Saccharomyces cerevisiae
Mdh1
-
 Saccharomyces cerevisiae
MDH2
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Saccharomyces cerevisiae
NADH dependent on Saccharomyces cerevisiae