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Literature summary for 1.1.1.37 extracted from

  • Eprintsev, A.T.; Falaleeva, M.I.; Stepanova, I.Y.; Parfenova, N.V.; Zuzu, M.
    Isolation, purification, and properties of malate dehydrogenase from sulfur bacterium Beggiatoa leptomitiformis (2003), Biol. Bull., 30, 243-247.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
L-malate inhibition constant: 3.65 mM Beggiatoa leptomitoformis
Zn2+ inhibition constant 1.7 mM Beggiatoa leptomitoformis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
NADH 25°C Beggiatoa leptomitoformis
0.02
-
oxaloacetate 25°C Beggiatoa leptomitoformis
0.53
-
NAD+ 25°C Beggiatoa leptomitoformis
0.67
-
L-malate 25°C Beggiatoa leptomitoformis

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ activation constant: 4.1 mM Beggiatoa leptomitoformis
Ca2+ activation constant: 3.3 mM Beggiatoa leptomitoformis
Mg2+ activation constant: 2.5 mM Beggiatoa leptomitoformis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
4 * 40000, SDS-PAGE Beggiatoa leptomitoformis
172000
-
gel filtration Beggiatoa leptomitoformis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Beggiatoa leptomitoformis the enzyme is involved in the tricarboxylic acid cycle supplying organic acids as the main source of carbon but not energy ?
-
?
additional information Beggiatoa leptomitoformis D-402 the enzyme is involved in the tricarboxylic acid cycle supplying organic acids as the main source of carbon but not energy ?
-
?

Organism

Organism UniProt Comment Textmining
Beggiatoa leptomitoformis
-
-
-
Beggiatoa leptomitoformis D-402
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Beggiatoa leptomitoformis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
20.43
-
-
Beggiatoa leptomitoformis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Beggiatoa leptomitoformis oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Beggiatoa leptomitoformis D-402 oxaloacetate + NADH + H+
-
r
additional information the enzyme is involved in the tricarboxylic acid cycle supplying organic acids as the main source of carbon but not energy Beggiatoa leptomitoformis ?
-
?
additional information the enzyme is involved in the tricarboxylic acid cycle supplying organic acids as the main source of carbon but not energy Beggiatoa leptomitoformis D-402 ?
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 40000, SDS-PAGE Beggiatoa leptomitoformis

Synonyms

Synonyms Comment Organism
MDH
-
Beggiatoa leptomitoformis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
oxidation of L-malate Beggiatoa leptomitoformis
55
-
reduction of oxaloacetate Beggiatoa leptomitoformis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.8
-
reduction of oxaloacetate Beggiatoa leptomitoformis
10.2
-
oxidation of L-malate Beggiatoa leptomitoformis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Beggiatoa leptomitoformis
NADH
-
Beggiatoa leptomitoformis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.7
-
Zn2+
-
Beggiatoa leptomitoformis
3.65
-
L-malate
-
Beggiatoa leptomitoformis