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Literature summary for 1.1.1.37 extracted from
- Malate dehydrogenases (1975), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 11, 369-396.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| L-malate | - |
Sus scrofa |  |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| cytoplasmic enzyme | Sus scrofa |
| s-MDH | Bos taurus |
| s-MDH | Ovis aries |
| s-MDH | Equus sp. |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Hydroxy-5-nitrobenzyl bromide | - |
Sus scrofa | |
| D-fructose 1,6-diphosphate | heart s-MDH, inhibits the binding of NADH | Bos taurus | |
| Hydroxymalonate | - |
Sus scrofa | |
| sulfite | - |
Bos taurus | |
| sulfite | - |
Gallus sp. | |
| sulfite | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Sus scrofa | 5737 | - |
| cytoplasm | - |
Bos taurus | 5737 | - |
| cytoplasm | - |
Neurospora crassa | 5737 | - |
| cytoplasm | - |
Phycomyces blakesleeanus | 5737 | - |
| cytoplasm | - |
Gallus sp. | 5737 | - |
| cytoplasm | - |
Drosophila virilis | 5737 | - |
| cytoplasm | - |
Equus sp. | 5737 | - |
| cytoplasm | - |
Thunnus albacares | 5737 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
| mitochondrion | - |
Neurospora crassa | 5739 | - |
| mitochondrion | - |
Gallus sp. | 5739 | - |
| mitochondrion | - |
Drosophila virilis | 5739 | - |
| mitochondrion | - |
Equus sp. | 5739 | - |
| mitochondrion | - |
Thunnus albacares | 5739 | - |
| mitochondrion | inner or outer membrane, m-MDH located in the inner membrane matrix | Sus scrofa | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33500 | - |
4 * 33500, SDS-PAGE | Bacillus subtilis |
| 33500 | - |
4 * 33500 | Escherichia coli |
| 67000 | - |
gel filtration | Sus scrofa |
| 67000 | - |
gel filtration | Neurospora crassa |
| 67000 | - |
gel filtration | Ovis aries |
| 67000 | - |
gel filtration | Gallus sp. |
| 67000 | - |
gel filtration | Thunnus albacares |
| 68000 | - |
- |
Drosophila virilis |
| 68000 | - |
- |
Salmo sp. |
| 68000 | - |
mitochondrial isoform | Sus scrofa |
| 72000 | - |
cytoplasmic isoform | Sus scrofa |
| 117000 | - |
- |
Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malate + NAD+ | Bacillus subtilis | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Escherichia coli | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Rattus norvegicus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Sus scrofa | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Bos taurus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Geobacillus stearothermophilus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Neurospora crassa | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Ovis aries | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Phycomyces blakesleeanus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Gallus sp. | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Drosophila virilis | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Equus sp. | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Thunnus albacares | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Salmo sp. | - |
oxaloacetate + NADH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Bos taurus | - |
ox | - |
| Drosophila virilis | - |
- |
- |
| Equus sp. | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Gallus sp. | - |
chicken | - |
| Geobacillus stearothermophilus | - |
- |
- |
| Neurospora crassa | - |
- |
- |
| Ovis aries | - |
lamb | - |
| Phycomyces blakesleeanus | - |
- |
- |
| Rattus norvegicus | - |
rat | - |
| Salmo sp. | - |
salmon | - |
| Sus scrofa | - |
pig | - |
| Thunnus albacares | - |
tuna | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bacillus subtilis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
| heart | - |
Bos taurus | - |
| heart | - |
Gallus sp. | - |
| heart | - |
Equus sp. | - |
| heart | - |
Thunnus albacares | - |
| heart | - |
Salmo sp. | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Gallus sp. | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NAD+ | - |
Bacillus subtilis | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Escherichia coli | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Rattus norvegicus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Bos taurus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Geobacillus stearothermophilus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Neurospora crassa | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Ovis aries | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Phycomyces blakesleeanus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Gallus sp. | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Drosophila virilis | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Equus sp. | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Thunnus albacares | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Salmo sp. | oxaloacetate + NADH + H+ | - |
r | |
| alpha-keto-malonate + NADH | reduced by m-MDH with half of the turnover number observed with oxaloacetate | Sus scrofa | ? + NAD+ | - |
? | |
| malate + NAD+ | - |
Bacillus subtilis | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Escherichia coli | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Rattus norvegicus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Bos taurus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Geobacillus stearothermophilus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Neurospora crassa | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Ovis aries | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Phycomyces blakesleeanus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Gallus sp. | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Drosophila virilis | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Equus sp. | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Thunnus albacares | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Salmo sp. | oxaloacetate + NADH + H+ | - |
r | |
| oxaloacetate + NADH | - |
Bacillus subtilis | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Escherichia coli | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Rattus norvegicus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Sus scrofa | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Bos taurus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Geobacillus stearothermophilus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Neurospora crassa | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Ovis aries | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Phycomyces blakesleeanus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Gallus sp. | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Drosophila virilis | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Equus sp. | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Thunnus albacares | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Salmo sp. | L-malate + NAD+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 33000-35000 | Sus scrofa |
| dimer | 2 * 33000-35000 | Bos taurus |
| tetramer | 4 * 33500, SDS-PAGE | Bacillus subtilis |
| tetramer | 4 * 33500 | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| m-MDH | - |
Sus scrofa |
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