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Literature summary for 1.1.1.359 extracted from

  • Haferkamp, P.; Kutschki, S.; Treichel, J.; Hemeda, H.; Sewczyk, K.; Hoffmann, D.; Zaparty, M.; Siebers, B.
    An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation? (2011), Biochem. Soc. Trans., 39, 77-81.
    View publication on PubMed
Search for more literature for 1.1.1.359

Cloned(Commentary)

Cloned (Comment) Organism
-
 Saccharolobus solfataricus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
 D-xylose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
0.25
-
 D-xylose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
0.44
-
 D-galactose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
0.5
-
 L-arabinose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
0.57
-
 D-galactose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
1.3
-
 beta-D-glucose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
1.5
-
 beta-D-glucose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharolobus solfataricus the enzyme iss involved in aldose catabolism via the branched variant of the Entner–Doudoroff pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q7LYI9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-glucose + NAD+ + H2O
-
 Saccharolobus solfataricus D-gluconate + NADH + 2 H+
-
 ir
beta-D-glucose + NADP+ + H2O
-
 Saccharolobus solfataricus D-gluconate + NADPH + 2 H+
-
 ir
D-galactose + NAD+ + H2O
-
 Saccharolobus solfataricus D-galactonate + NADH + 2 H+
-
 ?
D-galactose + NADP+ + H2O
-
 Saccharolobus solfataricus D-galactonate + NADPH + 2 H+
-
 ?
D-xylose + NAD+ + H2O
-
 Saccharolobus solfataricus ?
-
 ?
D-xylose + NADP+ + H2O
-
 Saccharolobus solfataricus ?
-
 ?
L-arabinose + NADP+ + H2O no activity with NAD+ Saccharolobus solfataricus ?
-
 ?
additional information the enzyme iss involved in aldose catabolism via the branched variant of the Entner–Doudoroff pathway Saccharolobus solfataricus ?
-
 ?

Synonyms

Synonyms Comment Organism
gdh-1
-
 Saccharolobus solfataricus
SSO3003
-
 Saccharolobus solfataricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
 assay at Saccharolobus solfataricus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
37
-
 D-galactose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
41
-
 L-arabinose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
47
-
 D-xylose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
47.7
-
 beta-D-glucose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
61
-
 D-galactose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
61
-
 D-xylose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
74.9
-
 beta-D-glucose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Saccharolobus solfataricus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharolobus solfataricus
NADP+
-
 Saccharolobus solfataricus

General Information

General Information Comment Organism
physiological function in glucose catabolism via the branched Entner–Doudoroff pathway the enzyme might acquire important function at higher D-glucose concentrations and in the presence of NAD+. It seems to have additional functions in the catabolism of D-galactose via the same pathway as well as in degradation pathways of D-xylose and L-arabinose Saccharolobus solfataricus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
36.7
-
 beta-D-glucose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
49.9
-
 beta-D-glucose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
82
-
 L-arabinose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
85
-
 D-galactose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus
108
-
 D-galactose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
245
-
 D-xylose pH 6.5, 70°C, cosubstrate: NAD+ Saccharolobus solfataricus
261
-
 D-xylose pH 6.5, 70°C, cosubstrate: NADP+ Saccharolobus solfataricus