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Literature summary for 1.1.1.357 extracted from

  • Trauger, J.W.; Jiang, A.; Stearns, B.A.; LoGrasso, P.V.
    Kinetics of allopregnanolone formation catalyzed by human 3alpha-hydroxysteroid dehydrogenase type III (AKR1C2) (2002), Biochemistry, 41, 13451-13459.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ursodeoxycholate micromolar inhibitor, competitive inhibitor versus 5alpha-dihydroprogesterone and uncompetitive inhibitor versus NADPH Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00007
-
NADPH in 100 mM potassium phosphate, pH 7.0, at 25°C Homo sapiens
0.00023
-
NADP+ in 100 mM potassium phosphate, pH 7.0, at 25°C Homo sapiens
0.0015
-
allopregnanolone in 100 mM potassium phosphate, pH 7.0, at 25°C Homo sapiens
0.0018
-
5alpha-dihydroprogesterone in 100 mM potassium phosphate, pH 7.0, at 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydroprogesterone + NADPH + H+ Homo sapiens
-
allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+
-
r
5beta-dihydroprogesterone + NADPH + H+ Homo sapiens
-
pregnanolone + NADP+
-
r
allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+ Homo sapiens
-
5alpha-dihydroprogesterone + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens P52895
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydroprogesterone + NADPH + H+
-
Homo sapiens allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+
-
r
5beta-dihydroprogesterone + NADPH + H+
-
Homo sapiens pregnanolone + NADP+
-
r
allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+
-
Homo sapiens 5alpha-dihydroprogesterone + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
3alpha-HSD type III
-
Homo sapiens
3alpha-hydroxysteroid dehydrogenase type III
-
Homo sapiens
AKR1C2
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.000017
-
allopregnanolone in 100 mM potassium phosphate, pH 7.0, at 25°C Homo sapiens
0.003
-
5alpha-dihydroprogesterone in 100 mM potassium phosphate, pH 7.0, at 25°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens
NADPH
-
Homo sapiens