Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ursodeoxycholate | micromolar inhibitor, competitive inhibitor versus 5alpha-dihydroprogesterone and uncompetitive inhibitor versus NADPH | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00007 | - |
NADPH | in 100 mM potassium phosphate, pH 7.0, at 25°C | Homo sapiens | |
0.00023 | - |
NADP+ | in 100 mM potassium phosphate, pH 7.0, at 25°C | Homo sapiens | |
0.0015 | - |
allopregnanolone | in 100 mM potassium phosphate, pH 7.0, at 25°C | Homo sapiens | |
0.0018 | - |
5alpha-dihydroprogesterone | in 100 mM potassium phosphate, pH 7.0, at 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydroprogesterone + NADPH + H+ | Homo sapiens | - |
allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+ | - |
r | |
5beta-dihydroprogesterone + NADPH + H+ | Homo sapiens | - |
pregnanolone + NADP+ | - |
r | |
allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+ | Homo sapiens | - |
5alpha-dihydroprogesterone + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52895 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydroprogesterone + NADPH + H+ | - |
Homo sapiens | allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+ | - |
r | |
5beta-dihydroprogesterone + NADPH + H+ | - |
Homo sapiens | pregnanolone + NADP+ | - |
r | |
allopregnanolone + 5alpha,20alpha-tetrahydroprogesterone + NADP+ | - |
Homo sapiens | 5alpha-dihydroprogesterone + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
3alpha-HSD type III | - |
Homo sapiens |
3alpha-hydroxysteroid dehydrogenase type III | - |
Homo sapiens |
AKR1C2 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000017 | - |
allopregnanolone | in 100 mM potassium phosphate, pH 7.0, at 25°C | Homo sapiens | |
0.003 | - |
5alpha-dihydroprogesterone | in 100 mM potassium phosphate, pH 7.0, at 25°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |