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Literature summary for 1.1.1.35 extracted from

  • Martens, G.A.; Vervoort, A.; Van de Casteele, M.; Stange, G.; Hellemans, K.; Van Thi, H.V.; Schuit, F.; Pipeleers, D.
    Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release (2007), J. Biol. Chem., 282, 21134-21144.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information inactivation of the enzyme by siRNA expression, the mutants show reduced beta-oxidation of fatty acids Homo sapiens
additional information inactivation of the enzyme by siRNA expression, the mutants show reduced beta-oxidation of fatty acids, shRNA-mediated HADHSC silencing affects induced absolute and fractional insulin secretion in INS1 832-13 cells and the cellular insulin content, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
x * 34000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxyacyl-CoA + NAD+ Homo sapiens the enzyme is involved in fatty acid beta-oxidation in beta cells, overview 3-oxoacyl-CoA + NADH + H+
-
?
(S)-3-hydroxyacyl-CoA + NAD+ Rattus norvegicus the enzyme is involved in fatty acid beta-oxidation in beta cells, overview 3-oxoacyl-CoA + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas immunohistochemic analysis, more intense staining in islets than in the surrounding exocrine tissue, being strongly present in insulin-positive cells and only weakly in glucagon-positive alpha cells Homo sapiens
-
pancreatic beta cell primary Homo sapiens
-
pancreatic beta cell primary Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxyacyl-CoA + NAD+
-
Homo sapiens 3-oxoacyl-CoA + NADH + H+
-
?
(S)-3-hydroxyacyl-CoA + NAD+
-
Rattus norvegicus 3-oxoacyl-CoA + NADH + H+
-
?
(S)-3-hydroxyacyl-CoA + NAD+ the enzyme is involved in fatty acid beta-oxidation in beta cells, overview Homo sapiens 3-oxoacyl-CoA + NADH + H+
-
?
(S)-3-hydroxyacyl-CoA + NAD+ the enzyme is involved in fatty acid beta-oxidation in beta cells, overview Rattus norvegicus 3-oxoacyl-CoA + NADH + H+
-
?

Subunits

Subunits Comment Organism
? x * 34000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
HADHSC
-
Homo sapiens
HADHSC
-
Rattus norvegicus
L-3-hydroxyacyl-CoA dehydrogenase, short chain
-
Homo sapiens
L-3-hydroxyacyl-CoA dehydrogenase, short chain
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus