Protein Variants | Comment | Organism |
---|---|---|
additional information | inactivation of the enzyme by siRNA expression, the mutants show reduced beta-oxidation of fatty acids | Homo sapiens |
additional information | inactivation of the enzyme by siRNA expression, the mutants show reduced beta-oxidation of fatty acids, shRNA-mediated HADHSC silencing affects induced absolute and fractional insulin secretion in INS1 832-13 cells and the cellular insulin content, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
x * 34000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxyacyl-CoA + NAD+ | Homo sapiens | the enzyme is involved in fatty acid beta-oxidation in beta cells, overview | 3-oxoacyl-CoA + NADH + H+ | - |
? | |
(S)-3-hydroxyacyl-CoA + NAD+ | Rattus norvegicus | the enzyme is involved in fatty acid beta-oxidation in beta cells, overview | 3-oxoacyl-CoA + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | immunohistochemic analysis, more intense staining in islets than in the surrounding exocrine tissue, being strongly present in insulin-positive cells and only weakly in glucagon-positive alpha cells | Homo sapiens | - |
pancreatic beta cell | primary | Homo sapiens | - |
pancreatic beta cell | primary | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxyacyl-CoA + NAD+ | - |
Homo sapiens | 3-oxoacyl-CoA + NADH + H+ | - |
? | |
(S)-3-hydroxyacyl-CoA + NAD+ | - |
Rattus norvegicus | 3-oxoacyl-CoA + NADH + H+ | - |
? | |
(S)-3-hydroxyacyl-CoA + NAD+ | the enzyme is involved in fatty acid beta-oxidation in beta cells, overview | Homo sapiens | 3-oxoacyl-CoA + NADH + H+ | - |
? | |
(S)-3-hydroxyacyl-CoA + NAD+ | the enzyme is involved in fatty acid beta-oxidation in beta cells, overview | Rattus norvegicus | 3-oxoacyl-CoA + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 34000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
HADHSC | - |
Homo sapiens |
HADHSC | - |
Rattus norvegicus |
L-3-hydroxyacyl-CoA dehydrogenase, short chain | - |
Homo sapiens |
L-3-hydroxyacyl-CoA dehydrogenase, short chain | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Rattus norvegicus |