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Literature summary for 1.1.1.34 extracted from

  • Mozzicafreddo, M.; Cuccioloni, M.; Eleuteri, A.; Angeletti, M.
    Rapid reverse phase-HPLC assay of HMG-CoA reductase activity (2010), J. Lipid Res., 51, 2460-2463.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Homo sapiens
-
mevalonate + CoA + 2 NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Homo sapiens
-
HCT-116 cell colon cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
Homo sapiens mevalonate + CoA + 2 NADP+
-
r
additional information method development for rapid and versatile reverse phase -HPLC monitoring for assaying HMGR activity capable of monitoring the levels of both substrates HMG-CoA and NADPH, and products CoA, mevalonate, and NADP+, method evaluation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
HMG-CoA reductase
-
Homo sapiens
HMGR
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens