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Literature summary for 1.1.1.34 extracted from

  • Perchellet, J.P.; Perchellet, E.M.; Crow, K.R.; Buszek, K.R.; Brown, N.; Ellappan, S.; Gao, G.; Luo, D.; Minatoya, M.; Lushington, G.H.
    Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins (2009), Int. J. Mol. Med., 24, 633-643.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
fluvastatin
-
Homo sapiens
lovastatin
-
Homo sapiens
mevastatin
-
Homo sapiens
additional information screening of eight-membered medium ring lactams and related tricyclic compounds, either seven-membered lactams, thiolactams or amines, for inhibitory potency, overview. The compounds are inhibitory also in the presence of increasing concentrations of NADPH, and are not affected by increasing concentrations of HMG-CoA. Medium ring lactams and existing statins may have different mechanisms of enzyme interaction and inhibition, molecular docking studies and comparisons using the HMG-CoA reductase statin-binding receptor model, overview. The ligands may occupy a narrow channel housing the pyridinium moiety on NADP+ Homo sapiens
pravastatin inhibitory in the presence of increasing concentrations of NADPH, but increasing concentrations of HMG-CoA block the HMG-CoA reductase-inhibiting activity Homo sapiens
simvastatin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Homo sapiens
-
mevalonate + CoA + 2 NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens P04035
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
Homo sapiens mevalonate + CoA + 2 NADP+
-
r

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
Homo sapiens
HMG-CoA reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
metabolism HMG-CoA reductase is the rate-limiting enzyme of cholesterol biosynthesis Homo sapiens